Viral findings in adult hematological patients with neutropenia.

PloS One
Lars OhrmalmThomas Tolfvenstam

Abstract

Until recently, viral infections in patients with hematological malignancies were concerns primarily in allogeneic hematopoietic stem cell transplant (HSCT) recipients. During the last years, changed treatment regimens for non-transplanted patients with hematological malignancies have had potential to increase the incidence of viral infections in this group. In this study, we have prospectively investigated the prevalence of a broad range of respiratory viruses in nasopharyngeal aspirate (NPA) as well as viruses that commonly reactivate after allogeneic HSCT. Patients with hematological malignancies and therapy induced neutropenia (n = 159) were screened regarding a broad range of common respiratory viruses in the nasopharynx and for viruses commonly detected in severely immunosuppressed patients in peripheral blood. Quantitative PCR was used for detection of viruses. A viral pathogen was detected in 35% of the patients. The detection rate was rather similar in blood (22%) and NPA (18%) with polyoma BK virus and rhinovirus as dominating pathogens in blood and NPA, respectively. Patients with chronic lymphocytic leukemia (CLL) (p<0.01) and patients with fever (p<0.001) were overrepresented in the virus-positive group. Furthermor...Continue Reading

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Oct 1, 2013·Expert Review of Anti-infective Therapy·Susanne Matthes-MartinThomas Lion
Apr 23, 2013·Diagnostic Microbiology and Infectious Disease·Emilie Vallières, Christian Renaud
Feb 11, 2018·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Noa LaviEmilia Hardak
Jan 9, 2013·Clinical Microbiology Reviews·Samantha E JacobsThomas J Walsh
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Jun 20, 2019·Leukemia & Lymphoma·Saeid ShahrabiNajmaldin Saki
Nov 7, 2019·Microorganisms·Cristian-Marian PopescuMihnea Zdrenghea
Mar 13, 2021·Frontiers in Medicine·Paraskevi C FragkouSotirios Tsiodras

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Methods Mentioned

BETA
PCR

Software Mentioned

PASW Statistics
Prism

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