PMID: 9658091Jul 11, 1998Paper

Viral genetic evolution in macaques infected with molecularly cloned simian immunodeficiency virus correlates with the extent of persistent viremia

Journal of Virology
Vanessa M HirschRobert Goeken

Abstract

Genetic evolution of the simian immunodeficiency virus (SIV) envelope glycoprotein was evaluated in a group of six macaques (Macaca nemestrina) infected with the molecularly cloned, moderately pathogenic SIVsm62d. The extent of envelope evolution was subsequently evaluated within the context of the individual pattern of viremia and disease outcome. Two macaques in this cohort developed AIDS by 1.5 years postinoculation (progressors), whereas the remaining four macaques remained asymptomatic (nonprogressors). Compared with the nonprogressor macaques, the two progressor macaques exhibited higher persistent plasma viremia, higher homologous neutralizing antibody titers, and more extensive mutation and evolution in the V1 region of envelope. Although clearly distinct in each of these parameters from the progressors, the four nonprogressors exhibited more individual variability with respect to the extent of persistent viremia and genetic evolution of the V1 region of envelope. The extent of V1 envelope varied from no apparent V1 evolution in a macaque with good viral containment to extensive evolution in one macaque with persistent viremia. This study underscores the critical role of persistent replication in the genetic evolution o...Continue Reading

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Citations

Apr 3, 2001·AIDS Research and Human Retroviruses·I S FortgangL S Levy
Feb 13, 2002·AIDS Research and Human Retroviruses·Mary Jo BurkhardEdward A Hoover
Jan 27, 2005·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jenna Rychert, Angela Martin Amedee

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