Viral hijacking of host caspases: an emerging category of pathogen-host interactions

Cell Death and Differentiation
Patrick F Connolly, Howard O Fearnhead

Abstract

Viruses co-evolve with their hosts, and many viruses have developed mechanisms to suppress or modify the host cell apoptotic response for their own benefit. Recently, evidence has emerged for the opposite strategy. Some viruses have developed the ability to co-opt apoptotic caspase activity to facilitate their own proliferation. In these strategies, viral proteins are cleaved by host caspases to create cleavage products with novel activities which facilitate viral replication. This represents a novel and interesting class of viral-host interactions, and also represents a new group of non-apoptotic roles for caspases. Here we review the evidence for such strategies, and discuss their origins and their implications for our understanding of the relationship between viral pathogenesis and programmed cell death.

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Citations

Oct 7, 2017·Viruses·Marc KvansakulMark G Hinds
Jul 20, 2018·Journal of Virology·Tate Tabtieng, Marta M Gaglia
Jan 25, 2018·Cell Death and Differentiation·Lorenzo GalluzziGuido Kroemer
Feb 17, 2018·Cell Death & Disease·Mark LötzerichUrs F Greber
Jul 20, 2019·Reviews in Medical Virology·Changbo QuQiuwei Pan
Aug 28, 2020·Journal of Virology·Roxana M Rodríguez StewartBernardo A Mainou
Jan 27, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Chiranjib ChakrabortySang-Soo Lee

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Methods Mentioned

BETA
nuclear translocation
glycosylation

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