PMID: 9429209Jan 1, 1997Paper

Viral induction of autoimmunity: mechanisms and examples in hepatology

Journal of Viral Hepatitis
Michael P Manns, P Obermayer-Straub

Abstract

Autoimmunity may be observed in chronic viral hepatitis, in particular hepatitis C and D. The hepatitis C virus (HCV) displays numerous interactions with the immune system. Hepatitis C virus induces a number of diseases of presumed autoimmune background, like mixed cryoglobulinaemia, glomerulonephritis, panarthritis, arthritis, thyroiditis and skin lesions. On the other hand a number of autoantibodies are observed during the course of hepatitis C. Of particular interest are liver/kidney microsomal antibodies (LKM). Their occurrence in viral hepatitis may indicate an increased risk for treatment with interferons. LKM antibodies in chronic hepatitis C recognize several autoepitopes differing from those in autoimmune hepatitis. Hepatitis C-associated LKM antibodies are more heterogeneous. They recognize either conformational or several distinct linear autoepitopes on cytochrome P450 2D6; they may also react with other microsomal proteins. Apart from their molecular weight at 59 and 70 kDa these microsomal antigens are not yet identified. Another model of virus-induced autoimmunity in man is chronic hepatitis D which always requires co-infection with hepatitis B. Hepatitis D is known to be associated with a number of autoantibodies...Continue Reading

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Citations

Oct 22, 2003·Journal of Hepatology·Georgios N DalekosMichael P Manns
Mar 29, 2000·Critical Reviews in Clinical Laboratory Sciences·L E Modahl, M M Lai
Mar 8, 2005·Drug Metabolism Reviews·Takaharu MizutaniTakashi Osaka
Mar 18, 2003·The American Journal of the Medical Sciences·Marlyn J Mayo
Apr 17, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·A González-KochR H Wiesner
May 5, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A J CzajaJ H Hoofnagle
Dec 14, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Rainer P WoitasUlrich Spengler
Feb 13, 2009·American Journal of Reproductive Immunology : AJRI·Yasuko ShiraishiMitsuaki Suzuki
Jun 2, 2001·Clinics in Liver Disease·R G Gish, A Mason
Sep 14, 2000·Baillière's Best Practice & Research. Clinical Rheumatology·M R Lövy, G Starkebaum
Nov 6, 2001·The American Journal of Gastroenterology·K Peoc'hC Johanet
Aug 6, 2008·Laboratory Investigation; a Journal of Technical Methods and Pathology·Chiou-Feng LinYee-Shin Lin
Apr 6, 2002·International Immunology·Thomas LuftEugene Maraskovsky
Mar 13, 2018·British Journal of Hospital Medicine·Eleni Theocharidou, Michael A Heneghan
Feb 24, 2001·The American Journal of Gastroenterology·K D FineJ Weinstein
Jul 16, 2014·World Journal of Hepatology·Fernando BessoneMarcelo G Roma
Sep 9, 1999·The American Journal of Surgical Pathology·L Rubbia-BrandtB Borisch
Jan 23, 1999·Current Opinion in Rheumatology·J Braun, J Sieper
Jan 10, 2002·European Journal of Gastroenterology & Hepatology·Georgios N DalekosMichael P Manns
Nov 24, 1999·The Journal of General Virology·A ChoukhiJ Dubuisson
May 12, 2020·Lupus·José A González-RegueiroRicardo U Macías-Rodríguez
Oct 20, 2004·Journal of Clinical Gastroenterology·Emanuele Durante-MangoniLuigi E Adinolfi

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