PMID: 8976191Dec 1, 1996Paper

Viral infection of transgenic mice expressing a viral protein in oligodendrocytes leads to chronic central nervous system autoimmune disease

The Journal of Experimental Medicine
C F EvansM B Oldstone

Abstract

One hypothesis for the etiology of central nervous system (CNS) autoimmune disease is that infection by a virus sharing antigenic epitopes with CNS antigens (molecular mimicry) elicits a virus-specific immune response that also recognizes self-epitopes. To address this hypothesis, transgenic mice were generated that express the nucleoprotein or glycoprotein of lymphocytic choriomeningitis virus (LCMV) as self in oligodendrocytes. Intraperitoneal infection with LCMV strain Armstrong led to infection of tissues in the periphery but not the CNS, and the virus was cleared within 7-14 d. After clearance, a chronic inflammation of the CNS resulted, accompanied by upregulation of CNS expression of MHC class I and II molecules. A second LCMV infection led to enhanced CNS pathology, characterized by loss of myelin and clinical motor dysfunction. Disease enhancement also occurred after a second infection with unrelated viruses that cross-activated LCMV-specific memory T cells. These findings indicate that chronic CNS autoimmune disease may be induced by infection with a virus sharing epitopes with a protein expressed in oligodendrocytes and this disease may be enhanced by a second infection with the same or an unrelated virus. These resu...Continue Reading

References

May 1, 1977·Infection and Immunity·M J Buchmeier, W E Rawls
Feb 1, 1991·Journal of Neuroscience Research·W F HickeyH Kimura
Jan 1, 1988·Annals of the New York Academy of Sciences·R S Fujinami
Sep 1, 1989·The Journal of Experimental Medicine·J L Whitton, M B Oldstone
Nov 1, 1989·Behavioral and Neural Biology·E W LaffanD A Weldon
Jan 1, 1989·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·J Julien, X Ferrer
Jun 8, 1985·Lancet·W A SibleyK Clark
Sep 1, 1987·Clinical Immunology and Immunopathology·D A HaflerH L Weiner
Jan 1, 1988·Annals of the New York Academy of Sciences·E LaviS R Weiss
Apr 1, 1988·Annals of Neurology·K W Selmaj, C S Raine
Sep 11, 1987·Cell·M B Oldstone
Apr 1, 1968·The Journal of Pharmacy and Pharmacology·B J Jones, D J Roberts
Sep 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·A K FieldM R Hilleman
Jan 1, 1980·Advances in Immunology·M J BuchmeierM B Oldstone
Aug 23, 1984·Nature·G H WongJ W Schrader
Aug 1, 1983·The Journal of General Virology·F J Dutko, M B Oldstone
Apr 25, 1995·Proceedings of the National Academy of Sciences of the United States of America·P HöllsbergD A Hafler
Nov 1, 1994·The Journal of Experimental Medicine·K BankiA Perl
Jan 1, 1994·Advances in Parasitology·R Hall
Jun 1, 1994·The Journal of Experimental Medicine·L K SelinR M Welsh

❮ Previous
Next ❯

Citations

Apr 11, 2006·Clinical & Developmental Immunology·Mette EjrnaesUrs Christen
Dec 13, 2006·Clinical & Developmental Immunology·Mette EjrnaesUrs Christen
Mar 29, 2002·Reviews in Medical Virology·Barry T Rouse, Shilpa Deshpande
Mar 20, 2002·Current Neurology and Neuroscience Reports·S Markovic-Plese, H F McFarland
Mar 9, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Marc S HorwitzNora Sarvetnick
Nov 10, 2000·Advanced Drug Delivery Reviews·M L Hedley
Mar 11, 1998·Current Opinion in Immunology·S Hausmann, K W Wucherpfennig
Aug 16, 2003·Microbes and Infection·Malin Flodström-Tullberg
Aug 25, 1999·Current Opinion in Microbiology·J L Whitton, R S Fujinami
Sep 1, 1997·Nature Medicine·Marc S HorwitzMichael B A Oldstone
Mar 26, 2009·Nature Reviews. Immunology·Christian MünzStephen D Miller
Jun 15, 2007·Nature Reviews. Microbiology·Raymond M Welsh, Robert S Fujinami
Dec 30, 1999·The New England Journal of Medicine·L J Albert, R D Inman
Nov 9, 2000·The Journal of Experimental Medicine·G WalzlT Hussell
Mar 9, 2005·The Journal of Experimental Medicine·Barbara Rehermann, Eui-Cheol Shin
Aug 18, 1999·Immunological Reviews·M S Horwitz, N Sarvetnick
Mar 1, 2003·Journal of Virology·Hanna LewickiMichael B A Oldstone
Jan 10, 2002·The Journal of Clinical Investigation·Marc S HorwitzNora Sarvetnick
Jul 18, 2001·The Journal of Clinical Investigation·J K OlsonS D Miller
Aug 18, 1999·Proceedings of the National Academy of Sciences of the United States of America·J HausmannP Staeheli
Apr 4, 2014·Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·Michael B A Oldstone
Jun 16, 2000·Journal of Neuroimmunology·M G von Herrath
Oct 6, 2009·Seminars in Immunopathology·Bettina SchreinerBurkhard Becher
Aug 18, 2010·Cellular and Molecular Life Sciences : CMLS·Tanja ScheiklRoland S Liblau
May 31, 2011·Autoimmunity Reviews·Uwe K ZettlRobert Patejdl
Jun 19, 2010·Progress in Neurobiology·Eilhard MixUwe K Zettl
Jan 23, 2010·Virus Research·T DaPalmaL M Kasman
Jun 1, 2007·Biochemical Pharmacology·Raymond J WinquistJugnu Jain
Jan 31, 2006·Cellular Microbiology·Kathleen R PageYukari C Manabe
Sep 16, 2006·Immunological Reviews·Monica J CarsonCorinne C Ploix
Aug 21, 2013·Immunological Reviews·Daniel R GettsStephen D Miller
Jun 12, 2010·Immunological Reviews·Raymond M WelshLiisa K Selin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.