Viral infections as potential triggers of type 1 diabetes

Diabetes/metabolism Research and Reviews
Nienke van der WerfJan-Luuk Hillebrands


During the last decades, the incidence of type 1 diabetes (T1D) has increased significantly, reaching percentages of 3% annually worldwide. This increase suggests that besides genetical factors environmental perturbations (including viral infections) are also involved in the pathogenesis of T1D. T1D has been associated with viral infections including enteroviruses, rubella, mumps, rotavirus, parvovirus and cytomegalovirus (CMV). Although correlations between clinical presentation with T1D and the occurrence of a viral infection that precedes the development of overt disease have been recognized, causalities between viruses and the diabetogenic process are still elusive and difficult to prove in humans. The use of experimental animal models is therefore indispensable, and indeed more insight in the mechanism by which viruses can modulate diabetogenesis has been provided by studies in rodent models for T1D such as the biobreeding (BB) rat, nonobese diabetic (NOD) mouse or specific transgenic mouse strains. Data from experimental animals as well as in vitro studies indicate that various viruses are clearly able to modulate the development of T1D via different mechanisms, including direct beta-cell lysis, bystander activation of au...Continue Reading


Jan 14, 1978·Lancet·M A MenserR D Bransby
Mar 3, 1979·Lancet·K P WardI A Auchterlonie
May 24, 1979·The New England Journal of Medicine·J W YoonA L Notkins
Sep 1, 1992·Nature Genetics·H J JacobE S Lander
Apr 1, 1992·Diabetes/metabolism Reviews·L CrisáA A Rossini
May 1, 1991·Journal of Clinical Microbiology·R F BishopG L Barnes
Apr 1, 1989·American Journal of Clinical Pathology·K NumazakiM A Wainberg
Nov 1, 1986·Diabetes·E J RayfieldJ W Yoon
Sep 1, 1987·The Journal of Clinical Investigation·R A EisenbergP L Cohen
Nov 22, 1968·Science·J E Craighead, M F McLane
Jul 26, 1980·Lancet·K HelmkeW Willems
Oct 1, 1980·Annals of Human Genetics·R S SpielmanC M Zmijewski
May 1, 1983·The Journal of Pediatrics·F KurtzG R Hauptmann
Jul 1, 1983·Metabolism: Clinical and Experimental·C I Chappel, W R Chappel
Jul 1, 1983·Metabolism: Clinical and Experimental·R JacksonG S Eisenbarth
Dec 1, 1982·Diabetes·P RubinsteinF Ginsberg-Fellner
Oct 1, 1981·Diabetes·R JacksonG S Eisenbarth
Apr 1, 1981·Diabetologia·J W YoonA B Jenson
Jan 1, 1982·The Journal of Pediatrics·H F ChampsaurC Bach
Jul 22, 1995·Lancet·G B ClementsK W Taylor
Jul 1, 1993·Diabetic Medicine : a Journal of the British Diabetic Association·S A IvarssonL Svanberg

❮ Previous
Next ❯


Dec 12, 2007·Diabetologia·H-Q QuC Polychronakos
Mar 14, 2013·Current Hypertension Reports·Heather LaGuardia, Rubin Zhang
Dec 14, 2011·Clinical Reviews in Allergy & Immunology·Maria De Santis, Carlo Selmi
Nov 19, 2011·Clinical Reviews in Allergy & Immunology·Matthew F CusickRobert S Fujinami
Jul 5, 2011·British Medical Bulletin·S L Thrower, P J Bingley
Sep 26, 2013·International Journal of Epidemiology·Jonathan LassenMads Melbye
Feb 4, 2010·Current Opinion in Endocrinology, Diabetes, and Obesity·Steven C PinoRita Bortell
Apr 18, 2008·Journal of Virology·Kate L GrahamBarbara S Coulson
Jul 21, 2010·PloS One·Hana ZoukConstantin Polychronakos
Jun 5, 2013·Journal of Molecular Endocrinology·Francesco Maria Egro
Dec 24, 2010·Critical Reviews in Immunology·Tomoh Matsumiya, Diana M Stafforini
Apr 1, 2010·Future Microbiology·Carolina S IlkowTom C Hobman
Jun 16, 2012·Indian Journal of Endocrinology and Metabolism·Juliana CasqueiroCresio Alves
Aug 2, 2013·International Journal of Biological Sciences·Yan-Ling WuWen Zhang
Mar 19, 2014·Acta Diabetologica·Angelico MendyHamidou Diallo
Jan 18, 2013·Mediators of Inflammation·Arlett Espinoza-JiménezLuis I Terrazas
May 22, 2013·Journal of Diabetes Research·Brian G PierceJohn P Mordes
Feb 18, 2016·Human Immunology·Rafael S de AlbuquerqueEduardo Antônio Donadi
Oct 15, 2013·Autoimmunity·Hana ZoukConstantin Polychronakos
May 22, 2013·Medical Hypotheses·Mona Landin-OlssonCharlotte Erlanson-Albertsson
Jan 16, 2016·Proteomics. Clinical Applications·Charles T SpencerSebastian Joyce
Sep 11, 2012·Journal of the American Academy of Dermatology·Yi-Chun ChenChia-Yu Chu
Jul 3, 2010·Journal of Comparative Pathology·K Doi
Jul 9, 2010·The Medical Clinics of North America·Yoko KanoTetsuo Shiohara
Sep 15, 2009·Human Immunology·Angela WahlWilliam H Hildebrand
Aug 25, 2009·Trends in Immunology·Shrimati Datta, Nora Sarvetnick
Jan 3, 2009·Social Science & Medicine·Laura J MillerRussell S Scott
Jan 10, 2008·Trends in Immunology·Dieter KabelitzLucienne Chatenoud
Dec 28, 2007·Neuromuscular Disorders : NMD·M Needham, F L Mastaglia
Oct 27, 2007·Journal of Ethnopharmacology·Elena Matteucci, Ottavio Giampietro
Oct 22, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R B Freeman
Jan 6, 2009·Annals of the New York Academy of Sciences·Rita BortellAldo A Rossini
Mar 15, 2008·Clinical Transplantation·En-Ling Leung KiManuel Pascual
Dec 3, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·F RamondettiUNKNOWN RIDI Study Group
Dec 21, 2010·Journal of Veterinary Emergency and Critical Care·Cristobal Navas de Solis, Jonathan H Foreman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.