Viral infections in prostate carcinomas in Chilean patients

Infectious Agents and Cancer
Hector RodríguezFrancisco Aguayo

Abstract

A few viruses have been detected in prostate cancer, however their role in the development of this malignancy has not been determined. The aim of this study was to analyze the presence and functionality of human papillomavirus (HPV) and polyomaviruses (BKPyV and JCPyV) in prostate carcinomas in Chilean patients. Sixty-nine primary prostate carcinomas were analyzed for the presence of HPV, BKPyV and JCPyV using standard polymerase chain reaction protocols. In addition, when samples were positive for HPyV, large T antigen (TAg) transcripts were analyzed using reverse transcriptase PCR. HPV and JCPyV were not detected in any specimens (0/69, 0 %); whereas, BKPyV was detected in 6/69 PCas (8.7 %). We did not find a statistically significant association between the presence of BKPyV and age (p = 0.198) or Gleason score (p = 0.268). In addition, 2/6 (33 %) BKPyV positive specimens showed detectable levels of TAg transcripts. There was no association between HPV or JCPyV presence and prostate cancer development. The presence of BKPyV in a small subset of prostate carcinomas in Chilean patients could indicate that this virus plays a potential role in prostate cancer development and requires further investigation.

References

Apr 1, 1992·Acta Obstetricia Et Gynecologica Scandinavica·T IwasakaH Sugimori
Apr 21, 1995·International Journal of Cancer. Journal International Du Cancer·C Moyret-LalleC Theillet
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·J S RhimG Jay
Jul 25, 2003·The New England Journal of Medicine·William G NelsonWilliam B Isaacs
Aug 12, 2003·Oncogene·Mauro TognonGiuseppe Barbanti-Brodano
Oct 7, 2003·Oncogene·Krzysztof Reiss, Kamel Khalili
Feb 4, 2006·Journal of Clinical Microbiology·Markus SchmittTim Waterboer
Apr 22, 2006·Advances in Experimental Medicine and Biology·Wendy A Knowles
Jun 7, 2007·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Sean K LauLawrence M Weiss
Dec 28, 2007·Journal of Virology·Dweepanita DasMichael J Imperiale
Jan 19, 2008·Science·Huichen FengPatrick S Moore
Feb 10, 2009·Nature Clinical Practice. Urology·Amit R Patel, Eric A Klein
Jun 10, 2010·The New England Journal of Medicine·Douglas R Lowy, Karl Munger
Jun 26, 2010·BMC Cancer·Margarita L Martinez-FierroAugusto Rojas-Martinez
Mar 15, 2011·Irish Journal of Medical Science·Y LinL Xie
May 26, 2011·Nature Reviews. Nephrology·Nina BabelPetra Reinke
Aug 30, 2012·Journal of Medical Virology·Ruth TachezyEva Hamsikova
Jul 4, 2013·Medical Microbiology and Immunology·Serena DelbuePasquale Ferrante
Sep 27, 2013·Journal of Virology·Naveed ShahzadMassimo Tommasino
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Oct 4, 2014·Oncotarget·Emma ShtivelmanChristopher P Evans

❮ Previous
Next ❯

Citations

Apr 11, 2018·Infectious Agents and Cancer·Jorge LevicanFrancisco Aguayo
Feb 1, 2020·Infectious Agents and Cancer·Juan P MuñozFrancisco Aguayo

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
genotyping
PCR

Software Mentioned

Stata

Related Concepts

Related Feeds

BK Virus Infection

BK virus infection is a significant complication of modern immunosuppression used in kidney transplantation. Discover the latest research on BK virus infection here.

Carcinoma, Bronchogenic

Bronchogenic Carcinoma is a malignant lung cancer arising in the epithelium of the bronchus or bronchiole. Discover the latest research on Bronchogenic Carcinoma here.