Viral infections of the central nervous system in elderly patients: a retrospective study

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
Saverio G ParisiGiorgio Palù

Abstract

Very few data exist on viral meningitis and encephalitis in elderly patients (>65 years old). This study investigated the detection of herpes simplex virus (HSV), varicella zoster virus (VZV), human herpes virus 6 (HHV-6), HHV-7, HHV-8, cytomegalovirus (CMV), Epstein-Barr virus (EBV), enterovirus (EV), human adenovirus (HAdV), human parechoviruses (HPeVs), and tick-borne encephalitis virus (TBEV) through real-time PCR (RT-PCR) in patients >65 years old who had cerebrospinal fluid (CSF) tested for a suspected central nervous system infection. A total of 2868 RT-PCRs were performed on 502 CSF samples. Overall, 65 positive RT-PCRs were found: 23 for HSV (35.4% of positives), 15 for EV (23.1% of positives), 14 for EBV (21.5% of positives), 12 for VZV (18.5% of positives), and one for CMV (1.5% of positives). A positive RT-PCR in CSF was detected in 24 (17.4%) patients aged ≥ 80 years and in 35 (9.6%) patients aged 65-79 years (p=0.02). VZV was more frequently detected in the oldest subjects (5.9% vs. 1.6%, p=0.03). HSV was the most common viral aetiology identified in the study, with VZV infection being recognized more frequently in those patients aged ≥ 80 years.

References

Jan 1, 1995·Pediatric Pathology & Laboratory Medicine : Journal of the Society for Pediatric Pathology, Affiliated with the International Paediatric Pathology Association·V JayM Zielenska
Feb 24, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·P G E Kennedy
Dec 15, 2012·Journal of Medical Virology·F de OryS Vázquez-Morón
Oct 31, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Sandro Zambito MarsalaErmenegildo Francavilla
Nov 6, 2014·Journal of the American Geriatrics Society·Amy Y WangRodrigo Hasbun
Dec 30, 2014·Neurology·Tarun D SinghAlejandro A Rabinstein

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Citations

Dec 17, 2016·Proceedings of the National Academy of Sciences of the United States of America·Eugene DrokhlyanskyConstance L Cepko
Jan 25, 2017·Current Opinion in Infectious Diseases·Fiona McGillTom Solomon
Jun 6, 2017·Journal of Central Nervous System Disease·P Brandon BookstaverSharon Weissman
Jul 8, 2018·BMJ Case Reports·Sarah Micallef, Ruth Galea
May 30, 2017·Current Pain and Headache Reports·Jon Rosenberg, Benjamin T Galen
Jun 14, 2017·Infection & chemotherapy·Areum DureyJin Soo Lee
Feb 16, 2020·Archives of Virology·Lieke BrouwerDasja Pajkrt
Apr 18, 2020·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Stefania KokkaliAikaterini Fitsiori
Jun 22, 2017·Age and Ageing·Henry A TapiaLuis F Varela

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