Viral Interactions with PDZ Domain-Containing Proteins-An Oncogenic Trait?

Pathogens
Claire D James, Sally Roberts

Abstract

Many of the human viruses with oncogenic capabilities, either in their natural host or in experimental systems (hepatitis B and C, human T cell leukaemia virus type 1, Kaposi sarcoma herpesvirus, human immunodeficiency virus, high-risk human papillomaviruses and adenovirus type 9), encode in their limited genome the ability to target cellular proteins containing PSD95/ DLG/ZO-1 (PDZ) interaction modules. In many cases (but not always), the viruses have evolved to bind the PDZ domains using the same short linear peptide motifs found in host protein-PDZ interactions, and in some cases regulate the interactions in a similar fashion by phosphorylation. What is striking is that the diverse viruses target a common subset of PDZ proteins that are intimately involved in controlling cell polarity and the structure and function of intercellular junctions, including tight junctions. Cell polarity is fundamental to the control of cell proliferation and cell survival and disruption of polarity and the signal transduction pathways involved is a key event in tumourigenesis. This review focuses on the oncogenic viruses and the role of targeting PDZ proteins in the virus life cycle and the contribution of virus-PDZ protein interactions to virus...Continue Reading

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Citations

Jan 4, 2017·Experimental and Molecular Pathology·Ana Laura CavatortaDaniela Gardiol
Jan 19, 2018·Viruses·Irina Suarez, Gilles Trave
Sep 22, 2016·MBio·Elizabeth A WhitePeter M Howley
Feb 28, 2019·The Journal of General Virology·Vanessa Sarabia-Vega, Lawrence Banks
Oct 11, 2019·Protein Science : a Publication of the Protein Society·Jordan ValgardsonJeanine F Amacher
Apr 18, 2020·Cytopathology : Official Journal of the British Society for Clinical Cytology·Aslam ShirazJohn Doorbar
Mar 23, 2018·PLoS Pathogens·Eléonore PérèsMadeleine Duc Dodon
Feb 2, 2019·Scientific Reports·Akshay DhingraAlbert Heim
Apr 22, 2020·Advanced Therapeutics·Nikolaj R ChristensenKristian Strømgaard
Oct 11, 2019·Journal of Virology·Nathaniel Edward Bennett SaiduVjekoslav Tomaić
Sep 27, 2020·Journal of Molecular Modeling·Alvaro GutiérrezAlvaro Cerda
May 27, 2021·Future Virology·Andrew P Rice, Jason T Kimata

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Methods Mentioned

BETA
two hybrid
ubiquitination
transgenic
GTPase

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