PMID: 229787Jan 1, 1979

Viral interference phenomena induced by foot-and-mouth disease temperature-sensitive mutants in bovine kidney cells

Archives of Virology
J POLATNICK, J Y Richmond

Abstract

Cultures of bovine kidney (BK) cells infected with temperature-sensitive (ts) mutants of foot-and-mouth disease virus (FMDV) were incubated at 38.5 degrees C, a temperature nonpermissive for mutant virus growth and RNA synthesis. The cells were subsequently resistant to viral growth and RNA synthesis when superinfected with wild-type FMDV and with heterologous fowl plague virus. The extent of interference was proportional to the multiplicity of infection of the ts mutant. It increased with time elapsed between infection with mutant and challenge infection, becoming greater than 99 percent after 24 hours. Interference was not proportional to decreased levels of cellular protein synthesis. The interference could be produced in the presence of actinomycin D, and thus was apparently mostly caused by the ts mutant itself rather than by interferon. The interference could not be produced in other less susceptible cell lines. Supernatant fluids from the BK cells infected with ts mutant virus interfered with wild-type FMD viral growth and RNA synthesis in fresh BK cells, and also showed low levels of activity in a vesicular stomatitis virus-plaque reduction assay. The properties of the supernatant fluid-interfering agent resembled to so...Continue Reading

References

Aug 1, 1991·Veterinary Immunology and Immunopathology·M Abolhassani, K L Jacobsen
Jun 24, 1999·International Journal of Health Services : Planning, Administration, Evaluation·N Krieger
Jan 1, 1981·International Journal of Health Services : Planning, Administration, Evaluation·A C Laurell

Citations

Jun 1, 1977·The Journal of General Virology·D McCahonJ Lake
Jan 1, 1968·Archiv für die gesamte Virusforschung·R F SellersW A Snowdon
Jan 1, 1970·Archiv für die gesamte Virusforschung·J Y Richmond
Jan 1, 1974·Archiv für die gesamte Virusforschung·J W McVicarA A Andersen
Oct 1, 1966·Journal of Bacteriology·J S YoungnerW R Stinebring
Apr 1, 1962·Proceedings of the Society for Experimental Biology and Medicine·Z DINTER, L PHILIPSON
Mar 1, 1962·Journal of Bacteriology·R A PLEDGER, J POLATNICK
Jan 1, 1962·Proceedings of the Society for Experimental Biology and Medicine·J POLATNICK, R A PLEDGER

Related Concepts

Aphthovirus
RNA Chemical Synthesis
Virus Replication
Bos taurus
Human leukocyte interferon
Foot-and-Mouth Disease
Kidney
Dental Plaque
Protein Biosynthesis
Etiology

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