Viral load in children with congenital cytomegalovirus infection identified on newborn hearing screening

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Jun-ichi KawadaYoshinori Ito

Abstract

Congenital cytomegalovirus (CMV) infection is the most common non-genetic cause of sensorineural hearing loss (SNHL) in children. However, congenital SNHL without other clinical abnormalities is rarely diagnosed as CMV-related in early infancy. The aim of this study was to identify and treat patients with congenital CMV-related SNHL or CMV-related clinical abnormalities other than SNHL. The association between CMV load and SNHL was also evaluated. Newborns who had abnormal hearing screening results or other clinical abnormalities were screened for congenital CMV infection by PCR of saliva or urine specimens, and identified infected patients were treated with valganciclovir (VGCV) for 6 weeks. The CMV load of patients with or without SNHL was compared at regular intervals during as well as after VGCV treatment. Of 127 infants with abnormal hearing screening results, and 31 infants with other clinical abnormalities, CMV infection was identified in 6 and 3 infants, respectively. After VGCV treatment, 1 case had improved hearing but the other 5 SNHL cases had little or no improvement. Among these 9 patients with or without SNHL at 1 year of age, there was no significant difference in CMV blood or urine load at diagnosis, but both w...Continue Reading

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Citations

Sep 30, 2016·Journal of Perinatology : Official Journal of the California Perinatal Association·Y KawanoY Ito
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Aug 8, 2021·Journal of the Pediatric Infectious Diseases Society·Minal M AminSheila C Dollard

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