Viral metagenomics, genetic and evolutionary characteristics of Crimean-Congo hemorrhagic fever orthonairovirus in humans, Kosovo

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
Petra EmmerichJonas Schmidt-Chanasit

Abstract

Crimean-Congo hemorrhagic fever orthonairovirus (CCHFV) is a tick-borne virus which causes severe disease in humans with fatality cases up to 30%. We investigated the genetic and evolutionary characteristics of CCHFV in Kosovo, in particular in humans and found that different virus variants of genotype V circulate, with Turkey as a possible origin for the progenitor of southern European CCHF outbreaks. Phylogenetic analyses also revealed a single introduction event and in situ evolution of CCHFV in this country. The viral metagenomics revealed a more abundant virome in the fatal CCHF cases and the presence of a novel tick-borne segmented RNA virus belonging to the recently discovered Jingmenvirus group which raises questions about the potential pathogenic effect of this novel virus on human and animal health.

Citations

Apr 1, 2020·Viruses·Ivan S KholodilovGalina G Karganova
Mar 23, 2019·BMJ Global Health·Laura T Mazzola, Cassandra Kelly-Cirino
Nov 21, 2019·Viruses·Ender DinçerKoray Ergünay
Sep 6, 2020·Viruses·Maja StanojevićYongzhen Zhang
May 6, 2019·Expert Review of Molecular Diagnostics·Anna Papa
Jul 20, 2019·Scientific Reports·Stephen SameroffChris Oura
Jan 23, 2019·Emerging Infectious Diseases·Salih AhmetiPetra Emmerich
Jul 11, 2019·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Suvi KuivanenOlli Vapalahti
Jul 21, 2020·Emerging Infectious Diseases·Kurt J VandegriftAmit Kapoor
Sep 20, 2020·Antiviral Research·Koray ErgünayAykut Özkul
Dec 15, 2020·Journal of Medical Entomology·Rafal Tokarz, W Ian Lipkin
May 13, 2021·Virus Evolution·Jing-Jing GuoYong-Zhen Zhang
May 25, 2021·Virus Evolution·Sofia ParaskevopoulouSandra Junglen

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