Viral metagenomics revealed novel betatorquevirus species in pediatric inpatients with encephalitis/meningoencephalitis from Ghana

Scientific Reports
Daniel EibachDaniel Cadar

Abstract

The cause of acute encephalitis/meningoencephalitis in pediatric patients remains often unexplained despite extensive investigations for large panel of pathogens. To explore a possible viral implication, we investigated the virome of cerebrospinal fluid specimens of 70 febrile pediatric inpatients with clinical compatible encephalitis/meningoencephalitis. Using viral metagenomics, we detected and genetically characterized three novel human Torque teno mini virus (TTMV) species (TTMV-G1-3). Phylogenetically, TTMV-G1-3 clustered in three novel monophyletic lineages within genus Betatorquevirus of the Anelloviridae family. TTMV-G1-3 were highly prevalent in diseased children, but absent in the healthy cohort which may indicate an association of TTMV species with febrile illness. With 2/3 detected malaria co-infection, it remains unclear if these novel anellovirus species are causative agents or increase disease severity by interaction with malaria parasites. The presence of the viruses 28 days after initiating antimalarial and/or antibiotic treatment suggests a still active viral infection likely as effect of parasitic and/or bacterial co-infection that may have initiated a modulated immune system environment for viral replication...Continue Reading

References

Dec 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·P L CollinsG W Wertz
Sep 12, 2000·Bioinformatics·D Martin, E Rybicki
Jan 10, 2002·Respiratory Medicine·M BandoY Sugiyama
Feb 28, 2002·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Ethel-Michele de VilliersHarald zur Hausen
Aug 2, 2002·The Journal of Biological Chemistry·Michelle A PetersGlenn F Browning
Dec 24, 2005·Journal of Medical Virology·Philippe BiaginiXavier de Lamballerie
Jun 29, 2007·Journal of Virology·Ludmila LeppikEthel-Michele de Villiers
Sep 15, 2009·Lancet·Katherine L O'BrienUNKNOWN Hib and Pneumococcal Global Burden of Disease Study Team
Oct 7, 2010·Reviews in Medical Virology·Fabrizio Maggi, Mauro Bendinelli
Feb 5, 2011·The American Journal of Tropical Medicine and Hygiene·Anne Caroline KrefisJürgen May
May 17, 2011·Nature Biotechnology·Manfred G GrabherrAviv Regev
Aug 2, 2011·Emerging Infectious Diseases·Laura A BenjaminTom Solomon
Jan 24, 2012·BMC Research Notes·Peter Simmonds
Mar 1, 2012·Molecular Biology and Evolution·Alexei J DrummondAndrew Rambaut
Aug 1, 2012·Nature Methods·Diego DarribaDavid Posada
Dec 12, 2012·PloS One·Erin McElvania TeKippeGregory A Storch
Apr 5, 2014·PloS One·Benjamin K ChanJohn D Kriesel
Jun 24, 2014·Journal of Paediatrics and Child Health·Philip N BrittonCheryl A Jones
Sep 27, 2014·PloS One·Brejnev Muhizi MuhireDarren Patrick Martin
Nov 18, 2014·Nature Methods·Benjamin BuchfinkDaniel H Huson
Nov 8, 2015·Virology·Kristýna HrazdilováVladimír Celer
Feb 7, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Benedikt HoganUNKNOWN Fever Without Source (FWS) Study Group

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Citations

Jun 16, 2019·Vaccines·Rosamund Chapman, Edward P Rybicki
Oct 18, 2019·Frontiers in Microbiology·Antonin BalSophie Trouillet-Assant
Dec 16, 2020·Journal of Translational Medicine·Bjørn Grinde
Nov 20, 2020·Open Forum Infectious Diseases·Karol PerlejewskiTomasz Laskus
Mar 27, 2021·Scientific Reports·María Cebriá-MendozaJosé M Cuevas
May 1, 2021·Emerging Microbes & Infections·Samuel CordeyLaurent Kaiser
Aug 13, 2021·Archives of Virology·Arvind VarsaniSimona Kraberger
Jan 12, 2022·American Journal of Primatology·Jacob D NegreyTony L Goldberg

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Datasets Mentioned

BETA
MH017546-MH017587

Methods Mentioned

BETA
PCR

Software Mentioned

Gblocks
Sequence Editor , Database and Analysis Platform
CLC workbench
BLASTx
Sequence Demarcation Tool
jModelTest
Geneious
BEAST
Gblock
ORF Finder

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