Viral oncolysates as human tumor vaccines.

International Reviews of Immunology
J SINKOVICS

Abstract

Postoncolytic immunity entails immune reactions acquired through an oncolytic virus infection or through repeated immunizations with viral oncolysates (or virally modified tumor cell membranes) that are valid and operational also against virally not modified tumor cells of the same type. NK cells react to budding virions, induce target cell lysis primarily but not exclusively by the production of granzymes and pore-forming proteins and operate without direction from memory cells. In contrast, immune T cells (including some TIL) are MHC-restricted, act under the direction of memory cells and lyse target cells primarily but not exclusively by the release of lymphotoxin (TNF beta) causing programmed cell death (apoptosis) through endonuclease activation and target cell DNA fragmentation. This author proposes that it is not NK, but the immune T cells that mediate postoncolytic immunity. Oncogene amplification may protect immortalized tumor cells even when expressing peptide antigens through MHC molecules against lymphotoxin-mediated apoptosis; but virally-infected tumor cells releasing budding virions remain susceptible to NK cells. Highly immunogenic viral oncolysates should present both budding virions for NK cells and processed ...Continue Reading

References

Jan 1, 1979·Advances in Cancer Research·H Kobayashi
Jan 1, 1979·Advances in Cancer Research·F C Austin, C W Boone
Feb 1, 1977·Cancer·M K WallackJ Johnson
Jan 1, 1978·European Urology·H TykkäT Tallberg
Jan 1, 1976·Annals of the New York Academy of Sciences·A A GreenK Smith
Mar 3, 1990·Lancet·K M DebatinP H Krammer
Mar 20, 1991·Journal of the National Cancer Institute·A SasakiR K Jain
Jan 1, 1990·Cancer Immunology, Immunotherapy : CII·S K HooverH D Bear
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D L ConferH S Jacob
Dec 19, 1990·Journal of the National Cancer Institute·M HerlynH Koprowski
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A E GoldfeldT Maniatis
Jan 1, 1988·Annals of the New York Academy of Sciences·J M PlateR L Hayes
Oct 15, 1989·International Journal of Cancer. Journal International Du Cancer·B Van den EyndeT Boon
Jan 1, 1989·Current Topics in Microbiology and Immunology·E R Podack
Feb 24, 1989·Cell·M B Oldstone
Jan 1, 1989·Urologia Internationalis·T SchärfeR Hohenfellner
Aug 25, 1989·Science·J L Marx
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A KnuthK H Meyer zum Büschenfelde
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M WettendorffD Herlyn
Oct 1, 1989·The Journal of Experimental Medicine·R C DukeJ D Young
Jun 1, 1986·The Journal of Experimental Medicine·H J WestlyP H Yuen
Jan 1, 1988·Cancer Treatment and Research·J A Bash, M K Wallack
May 1, 1988·The Journal of Experimental Medicine·T P LeistR M Zinkernagel
Jan 1, 1988·Cancer Immunology, Immunotherapy : CII·P AllavenaA Mantovani
Jan 1, 1986·Intervirology·D W Ehresmann, R N Hogan

❮ Previous
Next ❯

Citations

Feb 13, 2001·Vaccine·P Moingeon
Feb 19, 2000·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·J G Sinkovics, J C Horvath
Jun 1, 1997·Cancer Biotherapy & Radiopharmaceuticals·U ZornJ Atzpodien
Jan 6, 2012·Journal of Translational Medicine·Sandeep S PatilAladar A Szalay
Feb 19, 2008·Expert Review of Anticancer Therapy·Christina S ChuGeorge Coukos
Jan 3, 2015·Expert Opinion on Biological Therapy·Cheryl Lai-Lai ChiangLana E Kandalaft
Aug 27, 2005·Expert Opinion on Biological Therapy·George CoukosT-C Wu
Jan 15, 2011·Cancer Treatment Reviews·M G BourkeG C O'Sullivan
Apr 2, 2010·Seminars in Immunology·Cheryl Lai-Lai ChiangGeorge Coukos
May 1, 1995·Medical Hypotheses·J G Sinkovics, J Horvath
May 20, 1999·Acta Microbiologica Et Immunologica Hungarica·J C HorvathE Horvath
Jul 31, 2013·Oncoimmunology·Erika VacchelliLorenzo Galluzzi
Jan 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yoshihiro IkedaToshiyoshi Fujiwara

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.