Viral proteins and the mitochondrial apoptotic checkpoint

Cytokine & Growth Factor Reviews
H Everett, G McFadden

Abstract

Regulated cell death by apoptosis constitutes a primary host defense for counteracting invading viral pathogens. In recent years, advances in the field of apoptosis research have revealed that mitochondria and mitochondria-derived factors play a central role in regulating cellular commitment to apoptosis. Here we explore the role of viral proteins in modulating cell death pathways that are relayed via this mitochondrial checkpoint.

References

Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·L RaoE White
Dec 1, 1985·Medical Hypotheses·W M Clouston, J F Kerr
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·S HendersonA Rickinson
Jan 21, 1997·Proceedings of the National Academy of Sciences of the United States of America·E H ChengJ M Hardwick
May 2, 1998·The EMBO Journal·C ScaffidiM E Peter
Aug 28, 1998·Science·D R Green, J C Reed
Sep 2, 1998·Current Opinion in Immunology·M Barry, G McFadden
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·M NaritaY Tsujimoto
Apr 28, 1999·Trends in Microbiology·D E Griffin, J M Hardwick
Apr 28, 1999·Trends in Microbiology·H Everett, G McFadden
Jul 31, 1999·The Journal of Biological Chemistry·C ScaffidiM E Peter
Aug 13, 1999·Genes & Development·A GrossS J Korsmeyer
Oct 21, 1999·Journal of the National Cancer Institute·N J Nelson
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·V S GoldmacherT Chittenden
Nov 30, 1999·Immunology Letters·B Goldberg, R B Stricker
Jan 11, 2000·Molecular and Cellular Biology·R EskesJ C Martinou
Mar 29, 2000·Proceedings of the National Academy of Sciences of the United States of America·S ShimizuY Tsujimoto
May 3, 2000·The Journal of Experimental Medicine·H EverettG McFadden
Jun 29, 2000·Annual Review of Biochemistry·W C EarnshawS H Kaufmann
Feb 15, 2001·Cell Death and Differentiation·J C Reed, G Kroemer
Aug 30, 2007·Cell Cycle·Stefan A PaschenGeorg Häcker

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Citations

May 23, 2002·Biochimie·Anne-Sophie BelzacqCatherine Brenner
Jan 25, 2003·Annual Review of Immunology·Bruce T SeetGrant McFadden
Sep 11, 2004·Frontiers in Bioscience : a Journal and Virtual Library·Michael BindhuMichael D Lairmore
Oct 2, 2007·Biochimica Et Biophysica Acta·Steven J Werden, Grant McFadden
Dec 24, 2003·International Reviews of Immunology·Mei-Ling Li, Victor Stollar
Sep 7, 2001·Virology·H Everett, G McFadden
Jul 1, 2008·Advances in Virus Research·Steven J WerdenGrant McFadden
Feb 14, 2007·Veterinary Research·Marianne M StanfordGrant McFadden

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