Viral repression of fungal pheromone precursor gene expression.

Molecular and Cellular Biology
L ZhangN K Van Alfen

Abstract

Biological control of chestnut blight caused by the filamentous ascomycete Cryphonectria parasitica can be achieved with a virus that infects this fungus. This hypovirus causes a perturbation of fungal development that results in low virulence (hypovirulence), poor asexual sporulation, and female infertility without affecting fungal growth in culture. At the molecular level, the virus is known to affect the transcription of a number of fungal genes. Two of these genes, Vir1 and Vir2, produce abundant transcripts in noninfected strains of the fungus, but the transcripts are not detectable in virus-infected strains. We report here that these two genes encode the pheromone precursors of the Mat-2 mating type of the fungus; consequently, these genes have been renamed Mf2/1 and Mf2/2. To determine if the virus affects the mating systems of both mating types of this fungus, the pheromone precursor gene, Mf1/1, of a Mat-1 strain was cloned and likewise was found to be repressed in virus-infected strains. The suppression of transcription of the pheromone precursor genes of this fungus could be the cause of the mating defect of infected strains of the fungus. Although published reports suggest that a G alpha(i) subunit may be involved i...Continue Reading

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Citations

Jun 24, 2008·Fungal Genetics and Biology : FG & B·Hee-Kyoung KimSung-Hwan Yun
Jan 2, 2008·Fungal Genetics and Biology : FG & B·Jinjie ShangBaoshan Chen
Aug 26, 2010·Molecular Microbiology·Monika SchmollChristian P Kubicek
Apr 26, 2000·Fungal Genetics and Biology : FG & B·D Bell-Pedersen
Aug 14, 2012·Fungal Genetics and Biology : FG & B·Christian SeibelMonika Schmoll
Aug 12, 1999·Fungal Genetics and Biology : FG & B·W C ShenD J Ebbole
Jul 31, 2004·Annual Review of Phytopathology·Michael G Milgroom, Paolo Cortesi
Sep 14, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Zena Hadjivasiliou, Andrew Pomiankowski
Jan 22, 2011·Molecular Biology and Evolution·Simon H MartinEmma T Steenkamp
Jun 22, 2016·PLoS Genetics·Márcia David-PalmaPaula Gonçalves
Apr 15, 2011·Uirusu·Sotaro ChibaNobuhiro Suzuki
Jul 4, 2008·Acta Microbiologica Et Immunologica Hungarica·Erika Kothe
Aug 31, 2012·Microbiology and Molecular Biology Reviews : MMBR·Susan Michaelis, Jemima Barrowman
Apr 5, 2002·Heredity·Lorna A Casselton
Jan 10, 2009·Molecular Plant-microbe Interactions : MPMI·Debora Jacob-WilkNeal K Van Alfen
Nov 28, 2019·Proceedings of the National Academy of Sciences of the United States of America·Evan P StarrMary K Firestone
Oct 31, 2000·Applied and Environmental Microbiology·T L PeeverM G Milgroom
Sep 16, 2010·Phytopathology·Laura RostagnoMassimo Turina
Dec 13, 2002·Eukaryotic Cell·Hyojeong KimMary Anne Nelson
May 15, 2002·FEMS Microbiology Letters·Taha H Al-SamarraiPeter C Farley
Jun 11, 2019·Frontiers in Cellular and Infection Microbiology·Vaskar Thapa, Marilyn J Roossinck

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