Viral suppression and viral rebound among young adults living with HIV in Canada

Medicine
Alexis PalmerCanadian Observational Cohort (CANOC) Collaboration

Abstract

Describe the prevalence and covariates of viral suppression and subsequent rebound among younger (≤29 years old) compared with older adults.A retrospective clinical cohort study; eligibility criteria: documented HIV infection; resident of Canada; 18 years and over; first antiretroviral regimen comprised of at least 3 individual agents on or after January 1, 2000.Viral suppression and rebound were defined by at least 2 consecutive viral load measurements <50 or >50 HIV-1 RNA copies/mL, respectively, at least 30 days apart, in a 1-year period. Time to suppression and rebound were measured using the Kaplan-Meier method and Life Table estimates. Accelerated failure time models were used to determine factors independently associated with suppression and rebound.Younger adults experienced lower prevalence of viral suppression and shorter time to viral rebound compared with older adults. For younger adults, viral suppression was associated with being male and later era of combination antiretroviral initiation (cART) initiation. Viral rebound was associated with a history of injection drug use, Indigenous ancestry, baseline CD4 cell count >200, and initiating cART with a protease inhibitor (PI) containing regimen.The influence of age o...Continue Reading

References

Dec 15, 1995·American Journal of Epidemiology·S Greenland, W D Finkle
Jun 1, 1996·Journal of General Internal Medicine·N A HanchakB L Strom
Feb 18, 1998·JAMA : the Journal of the American Medical Association·R S HoggJ S Montaner
Nov 7, 1999·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·M E BelzerD J Tucker
May 2, 2000·American Journal of Preventive Medicine·S C KalichmanD Rompa
Jul 11, 2000·Nature Medicine·D D Ho, L Zhang
Sep 27, 2000·Proceedings of the National Academy of Sciences of the United States of America·J Martinez-PicadoR T D'Aquila
Jan 17, 2002·The New England Journal of Medicine·S L GortmakerUNKNOWN Pediatric AIDS Clinical Trials Group Protocol 219 Team
Jul 26, 2003·AIDS Patient Care and STDs·Maureen E LyonLawrence J D'Angelo
Jul 31, 2003·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Robert L JohnsonDouglas Bell
Jul 31, 2003·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Sally DoddsDouglas Bell
Oct 3, 2003·AIDS·Ard I van SighemUNKNOWN ATHENA Cohort Study Group
May 25, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Frederick L AlticeGerald H Friedland
Oct 9, 2004·Journal of Medical Internet Research·Sarah FlickerHarvey Skinner
Aug 3, 2005·Archives of Pediatrics & Adolescent Medicine·Debra A MurphyUNKNOWN Adolescent Medicine HIV/AIDS Research Network
Sep 20, 2005·The Journal of Infectious Diseases·Colette J SmithUNKNOWN United Kingdom Collaborative HIV Cohort Study Group
Feb 21, 2006·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Tiffany C VeinotEudice Goldberg
Mar 21, 2006·AIDS Research and Human Retroviruses·Bret J RudyUNKNOWN Pediatric Aids Clinical Trials Group 381 Study Team
Oct 24, 2008·Current Infectious Disease Reports·Jane M SimoniRobert Malow
Feb 14, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Ravi KavaseryShruti H Mehta
Feb 19, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Viviane D LimaJulio S G Montaner
Dec 2, 2009·Qualitative Health Research·Jane McCallSheryl Reimer-Kirkham
Jan 28, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Deborah KacanekIra B Wilson
Feb 17, 2010·International Journal of Epidemiology·Alexis K PalmerUNKNOWN CANOC Collaboration
Jun 4, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Allison L AgwuUNKNOWN HIV Research Network
Jul 2, 2011·Tropical Medicine & International Health : TM & IH·Katharina Kranzer, Nathan Ford
Jul 19, 2011·Lancet·Julio S G Montaner
Jul 20, 2011·The New England Journal of Medicine·Myron S CohenUNKNOWN HPTN 052 Study Team
Aug 10, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Patrick RyscavageBabafemi Taiwo
Aug 19, 2011·The New England Journal of Medicine·Mark A WainbergBluma G Brenner

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Citations

Feb 23, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jason A CrawJoseph Prejean
Dec 10, 2020·International Journal of STD & AIDS·Putu DuffKathleen Deering
Mar 13, 2021·AIDS·Thibaut Davy-MendezUNKNOWN North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) of IeDEA

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Software Mentioned

CANOC
SAS

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