Viral symbiosis and the holobiontic nature of the human genome

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
Francis Patrick Ryan

Abstract

The human genome is a holobiontic union of the mammalian nuclear genome, the mitochondrial genome and large numbers of endogenized retroviral genomes. This article defines and explores this symbiogenetic pattern of evolution, looking at the implications for human genetics, epigenetics, embryogenesis, physiology and the pathogenesis of inborn errors of metabolism and many other diseases.

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Mar 23, 2019·Annals of the New York Academy of Sciences·James A Shapiro
Aug 2, 2020·Progress in Biophysics and Molecular Biology·William B MillerJohn S Torday

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