Viral-toxin interactions and Parkinson's disease: poly I:C priming enhanced the neurodegenerative effects of paraquat.

Journal of Neuroinflammation
Jessica BobynShawn Hayley

Abstract

Parkinson's disease (PD) has been linked with exposure to a variety of environmental and immunological insults (for example, infectious pathogens) in which inflammatory and oxidative processes seem to be involved. In particular, epidemiological studies have found that pesticide exposure and infections may be linked with the incidence of PD. The present study sought to determine whether exposure to a viral mimic prior to exposure to pesticides would exacerbate PD-like pathology. Mice received a supra-nigral infusion of 5 μg of the double-stranded RNA viral analog, polyinosinic: polycytidylic acid (poly(I:C)), followed 2, 7 or 14 days later by administration of the pesticide, paraquat (nine 10 mg/kg injections over three weeks). As hypothesized, poly(I:C) pre-treatment enhanced dopamine (DA) neuron loss in the substantia nigra pars compacta elicited by subsequent paraquat treatment. The augmented neuronal loss was accompanied by robust signs of microglial activation, and by increased expression of the catalytic subunit (gp91) of the NADPH oxidase oxidative stress enzyme. However, the paraquat and poly(I:C) treatments did not appreciably affect home-cage activity, striatal DA terminals, or subventricular neurogenesis. These findin...Continue Reading

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Citations

Aug 16, 2013·Journal of Biomolecular Screening·Mariana Figuera-LosadaBarbara S Slusher
Feb 7, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Nafisa M JadavjiPatrice D Smith
Jan 20, 2016·Journal of Neuroinflammation·Antonio Carlos Pinheiro de OliveiraBernd L Fiebich
Oct 15, 2021·Journal of Neuroinflammation·Shawn Hayley, Hongyu Sun

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