Viral transactivating proteins

Annual Review of Genetics
J Flint, T Shenk

Abstract

Many viruses utilize the cellular transcription apparatus to express their genomes, and they encode transcriptional regulatory proteins that modulate the process. Here we review the current understanding of three viral regulatory proteins. The adenovirus E1A protein acts within the nucleus to regulate transcription through its ability to bind to other proteins. The herpes simplex type 1 virus VP16 protein acts within the nucleus to control transcription by binding to DNA in conjunction with cellular proteins. The human T-cell leukemia virus Tax protein influences transcription through interactions with cellular proteins in the nucleus as well as the cytoplasm.

References

Sep 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·S I ReedJ C Alwine
Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·N Jones, T Shenk
Jan 1, 1992·Journal of Virology·S P WeinheimerD R O'Boyle
Nov 1, 1992·Genes & Development·J L PomerantzP A Sharp
Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·L J Zhao, C Z Giam
Dec 1, 1992·Genes & Development·G E CrostonJ T Kadonaga
Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·E SetoT Shenk
Jun 1, 1992·Current Opinion in Cell Biology·L Zawel, D Reinberg
Nov 1, 1991·Trends in Biochemical Sciences·J HamM Yaniv
Jun 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·N HorikoshiR Weinmann
Mar 1, 1991·The Journal of Clinical Investigation·M R Smith, W C Greene
Jan 1, 1990·Genes & Development·C Rochette-EglyP Chambon

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Citations

May 26, 2005·Current Gastroenterology Reports·Christopher M HalloranJohn P Neoptolemos
Jun 21, 2012·Pathology Oncology Research : POR·Md ZeyaullahArif Ali
Jun 11, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·S GoverdhanaM G Castro
Sep 26, 2002·Virus Research·Adrienne L McNees, Linda R Gooding
Jun 5, 1998·Trends in Genetics : TIG·D Doyle, M Rogers
Feb 13, 2003·Molecular and Cellular Endocrinology·Shiyou Chen, S Stoney Simons
Dec 15, 2000·Trends in Microbiology·M O Hottiger, G J Nabel
Jan 19, 2000·Drug Discovery Today·I Wang, I Huang
May 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Francesca D FrentiuAdriana D Briscoe
Mar 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·B P SchlegelJ D Parvin
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·H HuangC D Allis
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·S YokoyamaN S Blow
Oct 25, 2002·Human Gene Therapy·Ruben Hernandez-AlcocebaMichael F Clarke
Oct 3, 1999·Current Opinion in Oncology·E Cesarman, E A Mesri
Aug 8, 1998·Genes & Development·E de StanchinaS W Lowe
Jul 3, 2003·The Plant Cell·Roisin C McGarrySondra G Lazarowitz
Jul 10, 1999·Immunological Reviews·J A Mahr, L R Gooding
Dec 28, 2002·Journal of Virology·Jeffrey A MahrLinda R Gooding
Sep 27, 2003·Journal of Virology·Hongxing ZhaoCatharina Svensson

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Methods Mentioned

BETA
transfection
footprinting
in vitro transcription
two-hybrid
ubiquitination
co-immunoprecipitation

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