Viral vector-mediated blockade of the endocrine stress-response modulates non-spatial memory.

Neuroscience Letters
Deveroux FergusonRobert Sapolsky

Abstract

Stress results in the release of glucocorticoids (GCs) which at high levels, impair performance on hippocampus-dependent tasks. Estrogen is neurotrophic and can rescue stress-induced memory impairments. Here we report the use of a viral vector to overexpress a chimeric gene (ER/GR) that converts the deleterious effects of glucocorticoids into beneficial estrogenic effects. A short immobilization stress regimen was sufficient to impair non-spatial memory. In contrast, viral vector-mediated overexpression of ER/GR in the dentate gyrus of the hippocampus protected against stress-induced impairments of non-spatial memory. These data add to the growing evidence that increasing estrogenic signaling can protect against the impairing effects of stress on non-spatial memory.

References

Nov 1, 1994·Behavioral and Neural Biology·V Luine, M Rodriguez
Oct 10, 1997·Neurobiology of Learning and Memory·M G Packard, L A Teather
Nov 1, 2000·Proceedings of the National Academy of Sciences of the United States of America·J McLaughlinR Sapolsky
Mar 13, 2001·Hormones and Behavior·M F KritzerJ K Robinson
Apr 3, 2001·Stroke; a Journal of Cerebral Circulation·M A YenariG K Steinberg
May 7, 2002·Learning & Memory·Kevin B Baker, Jeansok J Kim
Oct 10, 2002·Brain Research Bulletin·T J GouldP C Bickford
Jun 5, 2003·Endocrine·Veronica BisagnoVictoria Luine
Jun 18, 2003·Endocrinology·Victoria N LuineNeil J Maclusky
Jun 9, 2004·Neurobiology of Learning and Memory·Rebecca S HammondRobert W Stackman
Aug 10, 2004·Nature Neuroscience·D KauferR M Sapolsky
Oct 12, 2004·Hippocampus·Daniel T RadeckiTimothy J Teyler
Apr 6, 2005·Trends in Pharmacological Sciences·Keith T Akama, Bruce S McEwen
Jan 13, 2006·The Journal of Urology·Tomasz M BeerJeri S Janowsky
Nov 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrea NicholasRobert Sapolsky
Jul 27, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Deveroux Ferguson, Robert Sapolsky

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