Viral vector mediated continuous expression of interleukin-10 in DRG alleviates pain in type 1 diabetic animals

Molecular and Cellular Neurosciences
Vikram ThakurMunmun Chattopadhyay

Abstract

Painful diabetic neuropathy is a common and difficult to treat complication of diabetes. A growing body of evidence implicates the role of inflammatory mediators in the damage to the peripheral axons and in the pathogenesis of neuropathic pain. Increased expression of pro-inflammatory cytokines such as interleukin (IL)-1β and tumor necrosis factor (TNF)-α in the peripheral nervous system suggests the possibility of change in pain perception in diabetes. In this study we investigated that continuous delivery of IL10 in the nerve fibers achieved by HSV vector mediated transduction of dorsal root ganglion (DRG) in animals with Type 1 diabetes, blocks the nociceptive and stress responses in the DRG neurons by reducing IL1β expression along with inhibition of phosphorylation of p38 MAPK (mitogen-activated protein kinase) and protein kinase C (PKC). The continuous expression of IL10 also alters Toll like receptor (TLR)-4 expression in the DRG with increased expression of heat shock protein (HSP)-70 in conjunction with the reduction of pain. Taken together, this study suggests that macrophage activation in the peripheral nervous system may be involved in the pathogenesis of pain in Type 1 diabetes and therapeutic benefits of HSV media...Continue Reading

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Citations

Sep 7, 2016·Behavioural Brain Research·Nan-Qu HuangFeng Jin
Oct 20, 2017·Anesthesia and Analgesia·Nebojsa Nick KnezevicTony L Yaksh
May 2, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Baojian ZhangLi Zhang
Jun 9, 2018·Diseases·Kenneth Lundstrom
Jun 21, 2018·Frontiers in Pharmacology·Hui-Jing WangAnnemieke Kavelaars
Apr 17, 2021·Brain, Behavior, and Immunity·Khalil Ali AhmadYong-Xiang Wang
Apr 25, 2021·Journal of Neuroimmunology·Kathleen M Hagen, Shalina S Ousman
May 28, 2021·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Kufreobong E InyangGeoffroy Laumet
Sep 18, 2020·Current Gene Therapy·Nidhi PuranikJun-O Jin

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