PMID: 10810990May 16, 2000

Viral wasting syndrome of swine: experimental reproduction of postweaning multisystemic wasting syndrome in gnotobiotic swine by coinfection with porcine circovirus 2 and porcine parvovirus

Veterinary Pathology
S KrakowkaGordon M Allan

Abstract

One-day-old gnotobiotic piglets were inoculated intranasally with in vitro passaged porcine circovirus 1 (PCV-1), PCV-2, and porcine parvovirus (PPV) alone or in combination (PCV-1/PCV-2, PCV-1/PPV, and PCV-2/PPV). Piglets were evaluated for 1) the development of porcine postweaning multisystemic wasting syndrome (PMWS), 2) distribution of viral antigens by immunochemistry, and 3) viremia and the presence of viral DNA in nasal and ocular secretions and feces. All single agent-infected piglets and piglets infected with PCV-1/PCV-2 or PCV-1/PPV were clinically asymptomatic. They were transiently viremic and seroconverted to homologous virus(es). At termination of the study on postinfection day (PID) 35, microscopic lesions were restricted to focal inflammatory cell infiltrates in livers and myocardia. One piglet given PCV-1/PPV was PPV viremic for 2 weeks after infection and had lymphangiectasia of the spiral and descending colon associated with granulomatous inflammation. All four PCV-2/PPV-inoculated piglets developed PMWS, characterized by sudden onset of depression and anorexia, icterus, and submucosal edema. One piglet became moribund on PID 27, and the remaining three piglets were euthanatized between PID 27 and PID 30 beca...Continue Reading

References

Jan 1, 1991·Archives of Virology·D ToddM S McNulty
Jan 1, 1986·Archives of Virology·I TischerW Griem
Aug 1, 1994·Veterinary Microbiology·Gordon M AllanB M Adair
Jan 1, 1993·Archives of Virology·K OraveerakulT W Molitor
Jul 1, 1996·Veterinary Immunology and Immunopathology·S KrakowkaR Leunk
Sep 2, 1997·Proceedings of the National Academy of Sciences of the United States of America·X-J MengS U Emerson
Apr 4, 1998·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Gordon M AllanB M Adair
Apr 17, 1998·Veterinary Pathology·K D Rossow
Aug 15, 1998·Journal of Clinical Microbiology·Igor MorozovPrem S Paul
Sep 25, 1998·The Journal of General Virology·Brian M MeehanGordon M Allan
Jan 30, 1999·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·J A EllisFrancis McNeilly
Jan 1, 1988·Avian Pathology : Journal of the W.V.P.A·Y OtaakiY Nomura

Citations

Jun 8, 2014·Virus Research·Jie LiuPing Jiang
Jan 19, 2002·Journal of Comparative Pathology·E AlbinaAndré Jestin
Feb 13, 2008·The Veterinary Quarterly·Per WallgrenJ A Robertsson
Jan 25, 2005·The Veterinary Quarterly·Per WallgrenJ A Robertsson
Oct 29, 2002·The Veterinary Quarterly·J Segalés, Mariano Domingo
Nov 2, 2005·BMC Veterinary Research·Matti KiupelSuresh K Mittal
Jul 20, 2010·Virology Journal·Hong-ling XieYu-dong Cui
Feb 25, 2011·Journal of Clinical Microbiology·Ada G Cino-OzunaRaymond R R Rowland
Jun 26, 2002·Viral Immunology·A S Ladekjaer-Mikkelsen, Jens Nielsen
Jan 7, 2003·Viral Immunology·S KrakowkaGordon M Allan
Apr 6, 2004·Vaccine·Søren KamstrupAnette Bøtner
Dec 17, 2011·Virology Journal·Libin WenJieyuan Jiang
Dec 3, 2008·American Journal of Veterinary Research·S KrakowkaJohn A Ellis
May 19, 2005·Preventive Veterinary Medicine·S López-SoriaMariano Domingo
Dec 2, 2005·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Peter MeertsHans J Nauwynck
Apr 6, 2006·Animal Health Research Reviews·J SegalésMariano Domingo
Nov 23, 2010·Animal Health Research Reviews·A R Patterson, T Opriessnig
Dec 14, 2011·Animal Health Research Reviews·T OpriessnigP G Halbur
Apr 2, 2016·Research in Veterinary Science·Haiyan WangGuoqing Shao
Mar 19, 2013·Virus Research·Cheryl M T DvorakMichael P Murtaugh
Dec 20, 2011·Virus Research·Nicolas RoseAndré Jestin
Dec 20, 2011·Virus Research·Laila Darwich, Enric Mateu
Jul 26, 2011·Veterinary Microbiology·P C GaugerM E Kehrli
Apr 22, 2011·Veterinary Microbiology·Lester J PérezJosé I Núñez
Jul 11, 2008·Veterinary Microbiology·Anna TomásJ Segalés
Feb 29, 2008·Veterinary Immunology and Immunopathology·Tuija KekarainenJ Segalés
Jun 11, 2005·Immunology·Isabelle E VincentKenneth McCullough
Jul 17, 2003·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·A NúñezL Carrasco
Sep 29, 2009·Journal of Veterinary Internal Medicine·J GillespieV Buechner-Maxwell
Aug 16, 2006·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·Isao ShibataT Asai
Mar 23, 2011·Australian Veterinary Journal·M A O'DeaR B Richards
Jan 10, 2012·Transboundary and Emerging Diseases·X-J Meng
Mar 21, 2013·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Tomáš CsankMikuláš Levkut
Jun 30, 2004·Veterinary Microbiology·Chienjin HuangMaw-Sheng Chien
Jun 16, 2004·Research in Veterinary Science·G J WellenbergA R W Elbers
Apr 26, 2005·The Veterinary Journal·C Chae
May 17, 2011·Vaccine·Shasta D McClenahanChristine Uhlenhaut
Dec 29, 2000·The Journal of Veterinary Medical Science·T ShibaharaK Kadota
Mar 24, 2005·Acta Veterinaria Hungarica·S Belák
Jul 12, 2011·Preventive Veterinary Medicine·Pablo AlarconBarbara Wieland
Nov 30, 2010·Veterinary Microbiology·A R PattersonT Opriessnig
May 18, 2010·Preventive Veterinary Medicine·Vibeke Frøkjaer JensenElisabeth Okholm Nielsen
Jul 12, 2008·Virology·Esther SteinerKenneth McCullough
Oct 1, 2000·Avian Pathology : Journal of the W.V.P.A·D Todd
Jan 1, 2013·Annual Review of Animal Biosciences·Xiang-Jin Meng
Dec 25, 2007·Veterinary Microbiology·Louise LohseJens Nielsen
Nov 9, 2002·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Roman M PogranichniyMichael Daniels
Nov 9, 2002·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·F PallaresL J Hoffman
May 22, 2004·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Romeo E SanchezMaurice B Pensaert
May 30, 2002·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·J Kim, Chanhee Chae
Jun 14, 2012·Veterinary Pathology·T Opriessnig, Ingeborg M Langohr
Mar 1, 2012·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Ingeborg M LangohrRoman M Pogranichniy
Feb 27, 2014·Veterinary Pathology·John A Ellis
Jun 14, 2005·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·S KrakowkaGordon M Allan
Dec 12, 2003·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Gordon M AllanBrian Adair
Apr 10, 2002·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Francis McNeillyGordon M Allan
Aug 23, 2006·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Kathleen A McIntoshGreg D Appleyard
Nov 14, 2007·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·T OpriessnigP G Halbur
Apr 27, 2007·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Kenji KawashimaHiroshi Tsunemitsu
Nov 7, 2008·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·D M MadsonT Opriessnig
Feb 21, 2004·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·J Kim, Chanhee Chae
Mar 29, 2003·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Seamus KennedyGordon M Allan
Aug 3, 2001·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·S R BolinA L Hamel
Dec 21, 2017·Viruses·István MészárosZoltán Zádori
Sep 24, 2011·Clinical and Vaccine Immunology : CVI·K C O'NeillT Opriessnig
Mar 25, 2011·Clinical and Vaccine Immunology : CVI·Benjamin R TribleRaymond R R Rowland
Nov 7, 2002·The Veterinary Record·C ChoiC Chae
Nov 9, 2005·Clinical and Diagnostic Laboratory Immunology·N E McKeownX-J Meng
May 23, 2020·Australian Veterinary Journal·N K MoneJ Meers
Aug 16, 2016·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Fernanda S MarksJosé Reck
Apr 3, 2018·PeerJ·Jiankui LiuXiaoyan Yang
Jul 7, 2015·Veterinary Medicine and Science·Samuel Paulo CibulskiPaulo Michel Roehe
Oct 18, 2020·Scientific Reports·Sebastian Giraldo-RamirezJulian Ruiz-Saenz
Mar 1, 2017·The Veterinary Record·A AndersonS Unterer

Methods Mentioned

BETA
PCR

Related Concepts

Cell Transformation, Viral
Taenia Coli
Gnotobiotics
Immunocytochemistry
Swine Diseases
Viremia
Nested Polymerase Chain Reaction
Beak and feather disease virus
Parvovirus, Raccoon
Wasting Syndrome

Related Feeds

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.