Virally mediated immunotherapy for brain tumors

Neurosurgery Clinics of North America
Pankaj K AgarwallaWilliam T Curry

Abstract

Brain tumors are a leading cause of mortality and morbidity in the United States. Malignant brain tumors occur in approximately 80,000 adults. Furthermore, the average 5-year survival rate for malignant brain tumors across all ages and races is approximately 30% and has remained relatively static over the past few decades, showing the need for continued research and progress in brain tumor therapy. Improved techniques in molecular biology have expanded understanding of tumor genetics and permitted viral engineering and the anticancer therapeutic use of viruses as directly cytotoxic agents and as gene vectors. Preclinical models have shown promising antitumor effects, and generation of clinical grade vectors is feasible. In parallel to these developments, better understanding of antitumor immunity has been accompanied by progress in cancer immunotherapy, the goal of which is to stimulate host rejection of a growing tumor. This article reviews the intersection between the use of viral therapy and immunotherapy in the treatment of malignant gliomas. Each approach shows great promise on its own and in combined or integrated forms.

References

May 10, 1994·Proceedings of the National Academy of Sciences of the United States of America·D BarbaF H Gage
Apr 6, 2001·Seminars in Immunology·W A LoenenE J Wiertz
May 17, 2001·Proceedings of the National Academy of Sciences of the United States of America·T TodoP A Johnson
Feb 28, 2002·Molecular Therapy : the Journal of the American Society of Gene Therapy·Hiroaki WakimotoE Antonio Chiocca
Oct 31, 2002·Nature Immunology·Gavin P DunnRobert D Schreiber
Dec 3, 2002·Nature Reviews. Cancer·E Antonio Chiocca
Sep 4, 2003·The Cancer Journal·E Antonio ChioccaGiulia Fulci
Sep 4, 2003·The Cancer Journal·Nikolai G Rainov, Huan Ren
Jan 7, 2004·Nature Reviews. Cancer·Glenn Dranoff
Jan 30, 2004·Cancer Cell·Siddharth Balachandran, Glen N Barber
Mar 23, 2004·Annual Review of Immunology·Gavin P DunnRobert D Schreiber
Jul 6, 2004·Immunological Reviews·Bali Pulendran
Aug 17, 2004·Immunity·Gavin P DunnRobert D Schreiber
Nov 19, 2004·Nature·Siddharth BalachandranGlen N Barber
Jun 1, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·Fabian BenenciaGeorge Coukos
Sep 10, 2005·International Journal of Cancer. Journal International Du Cancer·Yukihiko IizukaMasahiro Toda
Oct 28, 2005·Current Gene Therapy·Eeva K Broberg, Veijo Hukkanen
Nov 1, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·Arnold I FreemanTali Siegal
Jan 24, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yasushi InoTomoki Todo
Aug 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Giulia FulciE Antonio Chiocca
Dec 14, 2006·Molecular Therapy : the Journal of the American Society of Gene Therapy·Anthony T PowerJohn C Bell
Apr 19, 2007·Cancer Immunology, Immunotherapy : CII·Ji-Yan LiuYi-Xin Zeng
Dec 15, 2007·Neuro-oncology·Gwendalyn D KingMaria G Castro
Feb 7, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Peter ForsythMark Hamilton
Feb 9, 2008·Neurosurgical Review·Lee A SelznickJohn Sampson
Feb 29, 2008·Journal of Neuroimmunology·Thomas SchneiderBernhard A Sabel
Mar 15, 2008·Nature Reviews. Immunology·Lewis L Lanier

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Related Papers

Molecular Therapy : the Journal of the American Society of Gene Therapy
Byram W BridleYonghong Wan
Journal of Midwifery & Women's Health
Corinne Audette, Jeannine Waterman
MMWR. Morbidity and Mortality Weekly Report
Centers for Disease Control and Prevention (CDC)
© 2022 Meta ULC. All rights reserved