Abstract
Daily, mutability and recombination of RNA viruses result in the production of million variants. All these rapid genomic changes directly influence the functional sites of the protein, its 3D structure or its drug resistances. Therefore, it is important to simulate these drastic switches to determine their effects on virus populations. Many computer programs are able to simulate specific variations in DNA genomes, but are generally non-adapted to RNA viruses. They simulate site-specific selection pressures, but rarely pressures on covariant or on higher order correlated sites and no at all on synthetic lethal groups. That is why we felt it important to create VIRAPOPS, a forward simulator that models specific RNA virus functions. It was designed for computational biologists, biologists and virologists. Free binaries are available through a software repository at http://petitjeanmichel.free.fr/itoweb.petitjean.freeware.html.
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Sep 4, 2014·Source Code for Biology and Medicine·Michel Petitjean, Anne Vanet
Apr 19, 2015·Biology Direct·Michel PetitjeanAnne Vanet
Nov 28, 2014·Journal of Virology·Deepak SharmaSudhanshu Vrati
Mar 14, 2019·Virus Evolution·Abbas JarianiKristof Theys
May 28, 2021·Virus Evolution·Bradley R Jones, Jeffrey B Joy