Virgin Coconut Oil-Induced Neuroprotection in Lipopolysaccharide-Challenged Rats is Mediated, in Part, Through Cholinergic, Anti-Oxidative and Anti-Inflammatory Pathways.

Journal of Dietary Supplements
Nur Syafiqah RahimKalavathy Ramasamy

Abstract

Neuroinflammation is associated with neuronal cell death and could lead to chronic neurodegeneration. This study investigated the neuroprotective potential of virgin coconut oil (VCO) against lipopolysaccharide (LPS)-induced cytotoxicity of neuroblastoma SK-N-SH cells. The findings were validated using Wistar rats, which were fed with 1-10 g/kg VCO for 31 days, exposed to LPS (0.25 mg/kg) and subjected to the Morris Water Maze Test. Brain homogenate was subjected to biochemical analyses and gene expression studies. α-Tocopherol (α-T; 150 mg/kg) served as the positive control. VCO (100 µg/mL) significantly (p < 0.01) improved SK-N-SH viability (+57%) and inhibited reactive oxygen species (-31%) in the presence of LPS. VCO (especially 10 g/kg) also significantly (p < 0.05) enhanced spatial memory of LPS-challenged rats. Brain homogenate of VCO-fed rats was presented with increased acetylcholine (+33%) and reduced acetylcholinesterase (-43%). The upregulated antioxidants may have reduced neuroinflammation [malondialdehyde (-51%), nitric oxide (-49%), Cox-2 (-64%) and iNos (-63%)] through upregulation of IL-10 (+30%) and downregulation of IL-1β (-65%) and Interferon-γ (-25%). There was also reduced expression of Bace-1 (-77%). VCO-...Continue Reading

References

Jan 1, 1993·Free Radical Research Communications·B C ScottO I Aruoma
Nov 20, 1998·The Journal of Pharmacy and Pharmacology·M A FernándezM D García
Aug 18, 1999·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·O VladimirovaB Kalman
May 2, 2001·The International Journal of Biochemistry & Cell Biology·A A Kheir-EldinH M Abd-ElGawad
Sep 25, 2001·IUBMB Life·R L VeechG F Cahill
Dec 3, 2003·Neurochemical Research·Denize R ZieglerCarlos-Alberto Gonçalves
Dec 6, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Syuan SungDomenico Praticò
Apr 1, 2004·Brain Research·Xiongwei ZhuGeorge Perry
Jul 17, 2004·Annals of Nutrition & Metabolism·Karl-Heinz WagnerIbrahim Elmadfa
Aug 27, 2004·Clinical Biochemistry·K G Nevin, T Rajamohan
Jan 11, 2005·Neurobiology of Aging·Robert E Mrak, W Sue T Griffin
Mar 30, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Patrick G Sullivan, Maile R Brown
Feb 24, 2007·Molecular Aspects of Medicine·Elke ReiterStephan Christen
Mar 31, 2007·Life Sciences·Ethika TyagiRakesh Shukla
Nov 6, 2007·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Silke WalterKlaus Fassbender
Aug 12, 2008·Journal of Neurochemistry·Kai-Hui SunKavita Shah
Dec 3, 2008·Phytotherapy Research : PTR·Muralikrishnan DhanasekaranBala V Manyam
Dec 31, 2008·International Journal of Food Sciences and Nutrition·A M MarinaI Amin
May 27, 2009·British Journal of Pharmacology·S FallariniG Lombardi
Jun 6, 2009·Journal of Internal Medicine·M Rosas-Ballina, K J Tracey
Oct 3, 2009·Cellular and Molecular Neurobiology·M Omer BostanciFaruk Bagirici
Nov 26, 2009·BMC Complementary and Alternative Medicine·Nurul A M N HazalinAbu Bakar Abdul Majeed
Feb 9, 2010·Nature Reviews. Neurology·Cynthia A Lemere, Eliezer Masliah
Feb 27, 2010·European Journal of Pharmacology·Asadollah ZarifkarMaryam Moosavi
May 11, 2010·European Journal of Pharmacology·Ethika TyagiRakesh Shukla
Dec 7, 2010·Free Radical Biology & Medicine·Magali Dumont, M Flint Beal
Dec 7, 2010·Neurobiology of Aging·Robert KrikorianDeborah J Clegg
Apr 2, 2011·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Z A ZakariaK Long
Nov 24, 2011·Neurochemistry International·Dong-Young ChoiMoon Soon Lee
Dec 14, 2011·Journal of Neuroinflammation·Jeroen J M HoozemansWillem A van Gool

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