Virgin coconut oil maintains redox status and improves glycemic conditions in high fructose fed rats

Journal of Food Science and Technology
Arunaksharan NarayanankuttyAchuthan C Raghavamenon

Abstract

Virgin Coconut Oil (VCO), extracted from fresh coconut kernel possess similar fatty acid composition to that of Copra Oil (CO), a product of dried kernel. Although CO forms the predominant dietary constituent in south India, VCO is being promoted for healthy life due to its constituent antioxidant molecules. High fructose containing CO is an established model for insulin resistance and steatohepatitis in rodents. In this study, replacement of CO with VCO in high fructose diet markedly improved the glucose metabolism and dyslipidemia. The animals fed VCO diet had only 17 % increase in blood glucose level compared to CO fed animals (46 %). Increased level of GSH and antioxidant enzyme activities in VCO fed rats indicate improved hepatic redox status. Reduced lipid peroxidation and carbonyl adducts in VCO fed rats well corroborate with the histopathological findings that hepatic damage and steatosis were comparatively reduced than the CO fed animals. These results suggest that VCO could be an efficient nutraceutical in preventing the development of diet induced insulin resistance and associated complications possibly through its antioxidant efficacy.

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Citations

Sep 30, 2016·Plant Foods for Human Nutrition·Devi Lekshmi SheelaAchuthan C Raghavamenon
Dec 21, 2016·Toxicology Mechanisms and Methods·Arunaksharan NarayanankuttyAchuthan C Raghavamenon
Apr 18, 2017·Toxicology Mechanisms and Methods·Soorya Parathodi IllamAchuthan C Raghavamenon
Sep 20, 2019·Journal of Complementary & Integrative Medicine·Lalgi HimaSrinivasan ThyagaRajan
Jun 13, 2020·Nutrition and Cancer·Arunaksharan NarayanankuttyAchuthan C Raghavamenon
Feb 14, 2020·Endocrine, Metabolic & Immune Disorders Drug Targets·Laura E Gutiérrez-PliegoRoxana Valdés-Ramos
Sep 2, 2017·Journal of the Science of Food and Agriculture·Arunaksharan NarayanankuttyAchuthan C Raghavamenon
Oct 7, 2020·Journal of the Science of Food and Agriculture·Afka DeenRuvini Liyanage
Dec 15, 2020·Drug and Chemical Toxicology·Dhilna MalayilArunaksharan Narayanankutty
Feb 8, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Parinaz NikooeiAli Vasheghani-Farahani
Apr 18, 2021·Journal of Food Science·Soorya Parathodi IllamAchuthan Chathrattil Raghavamenon
Aug 20, 2021·Drug and Chemical Toxicology·Soorya Parathodi IllamAchuthan C Raghavamenon

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