Virgin olive oil blended polyurethane micro/nanofibers ornamented with copper oxide nanocrystals for biomedical applications

International Journal of Nanomedicine
Touseef AmnaInho Hwang

Abstract

Recently, substantial interest has been generated in using electrospun biomimetic nanofibers of hybrids, particularly organic/inorganic, to engineer different tissues. The present work, for the first time, introduced a unique natural and synthetic hybrid micronanofiber wound dressing, composed of virgin olive oil/copper oxide nanocrystals and polyurethane (PU), developed via facile electrospinning. The as-spun organic/inorganic hybrid micronanofibers were characterized by scanning electron microscopy (SEM), energy dispersive X-ray analysis, X-ray diffraction, electron probe microanalysis, and transmission electron microscopy. The interaction of cells with scaffold was studied by culturing NIH 3T3 fibroblasts on an as-spun hybrid micronanofibrous mat, and viability, proliferation, and growth were assessed. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay results and SEM observation showed that the hybrid micronanofibrous scaffold was noncytotoxic to fibroblast cell culture and was found to benefit cell attachment and proliferation. Hence our results suggest the potential utilization of as-spun micronanoscaffolds for tissue engineering. Copper oxide-olive oil/PU wound dressing may exert its positive benefici...Continue Reading

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Citations

Dec 4, 2016·Applied Biochemistry and Biotechnology·Musarat AminaMyung-Seob Khil
Jun 25, 2017·Trends in Biotechnology·Morgane BerthetClaire Monge
Jul 22, 2017·Advanced Functional Materials·Jisheng XiaoGuillermo A Ameer
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Bushra NaureenFarina Muhamad
Nov 12, 2019·Bioactive Materials·Maria P Nikolova, Murthy S Chavali
May 1, 2021·International Journal of Molecular Sciences·Anjum Hamid RatherFaheem A Sheikh
Jun 1, 2021·Journal of Biomaterials Science. Polymer Edition·Cansu ArasEsra Karaca

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Methods Mentioned

BETA
scanning
X-ray
electron probe microanalysis
enzyme-linked immunosorbent assay
transmission electron micro scopy

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