Virilising Sertoli-Leydig cell tumour associated with thyroid papillary carcinoma: case report and general considerations

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Catalina PoianaMihail Coculescu

Abstract

We present a case of a Sertoli-Leydig cell tumour manifested with progressive hirsutism, frontal alopecia and secondary amenorrhea in a 46-years-old female, evolving for 6 years until presentation. Serum testosterone level was 8.01 ng/ml and gonadotropic hormones were LH 8.57 mIU/ml and FSH 9.52 mIU/ml. Computed tomography revealed a dense, solid, heterogeneous mass of 3.5/2.8 cm in the right ovary. Bilateral ovariectomy and hysterectomy were performed. The histopathological report mentioned a Sertoli-Leydig cell tumor with intermediate grade of differentiation. Immunohistochemical stains showed positive reaction for alpha-inhibin, calretin and for progesterone receptor. The testosterone levels dramatically decreased after surgery (0.31 ng/ml) while levels of gonadotropes increased: LH 40.98 mIU/ml and FSH 50.41 mIU/ml. At 6 months follow-up the diagnosis of a left lobe thyroid nodule leaded to fine needle aspiration biopsy with suspicion of papillary carcinoma. Total thyroidectomy established the diagnosis of thyroid papillary carcinoma (2.17/2.18 cm) T2N0M0, stage II, followed by radioiodine administration. This is to our knowledge the first presented case of ovarian Sertoli-Leydig cell tumour associated with papillary thyroi...Continue Reading

References

May 1, 1992·The Journal of Clinical Investigation·M SantoroN Berger
Aug 1, 1985·The American Journal of Surgical Pathology·R H Young, R E Scully
Jan 1, 1974·Cancer·R D JensenJ F Fraumeni
Apr 1, 1981·American Journal of Clinical Pathology·P K O'Brien, D L Wilansky
Jan 1, 1982·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·A TalermanM C Anderson
Jun 1, 1984·The American Journal of Surgical Pathology·C Zaloudek, H J Norris
Dec 30, 1993·European Journal of Obstetrics, Gynecology, and Reproductive Biology·A A Kasperlik-ZaluskaM Wysocki
Jan 13, 2005·The American Journal of Surgical Pathology·Esther OlivaRobert H Young
Jul 1, 2006·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Lawrence M Roth
Jan 2, 2007·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Chengquan ZhaoRussell Vang
Feb 10, 2007·Maturitas·Olga Asín SanzJuan Luis Zambrano Alcazar
Apr 3, 2008·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Poonam SachdevaDeepak Kumar Singh

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Citations

Mar 18, 2016·Virchows Archiv : an International Journal of Pathology·Emeline DurieuxMojgan Devouassoux-Shisheboran
Mar 15, 2018·American Journal of Clinical Pathology·Irene GulloManuel Sobrinho-Simões
Mar 24, 2020·Problemy e̊ndokrinologii·M F KalashnikovaV V Fadeyev
Mar 16, 2021·European Thyroid Journal·Sule CanberkValdemar Máximo
Oct 16, 2021·Experimental and Therapeutic Medicine·Florica SandruMara Carsote

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