Virion-Associated Polyamines Transmit with Bunyaviruses to Maintain Infectivity and Promote Entry.

ACS Infectious Diseases
Vincent MastrodomenicoBryan C Mounce

Abstract

Viruses require host cell metabolites to productively infect, and the mechanisms by which viruses usurp these molecules are diverse. One group of cellular metabolites important in virus infection is the polyamines, small positively charged molecules involved in cell cycle, translation, and nucleic acid metabolism, among other cellular functions. Polyamines support replication of diverse viruses, and they are important for processes such as transcription, translation, and viral protein enzymatic activity. Rift Valley fever virus (RVFV) is a negative and ambisense RNA virus that requires polyamines to produce infectious particles. In polyamine depleted conditions, noninfectious particles are produced that interfere with virus replication and stimulate immune signaling. Here, we find that RVFV relies on virion-associated polyamines to maintain infectivity and enhance viral entry. We show that RVFV replication is facilitated by a limited set of polyamines and that spermidine and closely related molecules associate with purified virions and transmit from cell to cell during infection. Virion-associated spermidine maintains virion infectivity, as virions devoid of polyamines rapidly lose infectivity and are temperature sensitive. Fur...Continue Reading

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Citations

Dec 10, 2020·Infection and Drug Resistance·Mingyuan HuangJincheng Zeng
Sep 24, 2020·ACS Infectious Diseases·Mason R FirpoBryan C Mounce

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