Virion-Like Membrane-Breaking Nanoparticles with Tumor-Activated Cell-and-Tissue Dual-Penetration Conquer Impermeable Cancer

Advanced Materials
Xiao ZhangZhongwei Gu

Abstract

Poor drug penetration into tumor cells and tissues is a worldwide difficulty in cancer therapy. A strategy is developed for virion-like membrane-breaking nanoparticles (MBNs) to smoothly accomplish tumor-activated cell-and-tissue dual-penetration for surmounting impermeable drug-resistant cancer. Tailor-made dendritic arginine-rich peptide prodrugs are designed to mimic viral protein transduction domains and globular protein architectures. Attractively, these protein mimics self-assemble into virion-like nanoparticles in aqueous solution, having highly ordered secondary structure. Tumor-specific acidity conditions would activate the membrane-breaking ability of these virion-like nanoparticles to perforate artificial and natural membrane systems. As expected, MBNs achieve highly efficient drug penetration into drug-resistant human ovarian (SKOV3/R) cancer cells. Most importantly, the well-organized MBNs can pass through endothelial/tumor cells and spread from one cell to another one. Intravenous injection of MBNs into nude mice bearing impermeable SKOV3/R tumors suggests that the MBNs can recognize the tumor tissue after prolonged blood circulation, evoke the membrane-breaking function for robust transvascular extravasation, and...Continue Reading

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Citations

Mar 5, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yuli BaiYuan Huang
Sep 12, 2020·Nanomedicine·Neha MehrotraHarpal Singh
Oct 1, 2020·Biomaterials Science·Tongyi ShangBin Yang
Sep 22, 2020·Advanced Functional Materials·Xiao ZhangMin Lee
Feb 14, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Long ZhangXingjie Zan
Dec 2, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jianqin YanBin He
Dec 24, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Xihui GaoChangyou Zhan
Jun 29, 2021·Seminars in Cancer Biology·Xiao Yin MaFei Wen
Jul 3, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Cai YaoQi Wang
Dec 21, 2019·ACS Medicinal Chemistry Letters·Zhuangzhuang ZhangZhongwei Gu
Oct 10, 2021·Advanced Healthcare Materials·Zhaoyu MaHeyou Han
Oct 15, 2021·Nanotechnology·Chenlei WangYeteng Zhong

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