Virion structures and genome delivery of honeybee viruses.

Current Opinion in Virology
Michaela ProcházkováPavel Plevka

Abstract

The western honeybee is the primary pollinator of numerous food crops. Furthermore, honeybees are essential for ecosystem stability by sustaining the diversity and abundance of wild flowering plants. However, the worldwide population of honeybees is under pressure from environmental stress and pathogens. Viruses from the families Iflaviridae and Dicistroviridae, together with their vector, the parasitic mite Varroa destructor, are the major threat to the world's honeybees. Dicistroviruses and iflaviruses have capsids with icosahedral symmetries. Acidic pH triggers the genome release of both dicistroviruses and iflaviruses. The capsids of iflaviruses expand, whereas those of dicistroviruses remain compact until the genome release. Furthermore, dicistroviruses use inner capsid proteins, whereas iflaviruses employ protruding domains or minor capsid proteins from the virion surface to penetrate membranes and deliver their genomes into the cell cytoplasm. The structural characterization of the infection process opens up possibilities for the development of antiviral compounds.

Citations

Feb 2, 2021·Science Advances·Karel ŠkubníkPavel Plevka
May 6, 2021·Proceedings of the National Academy of Sciences of the United States of America·Dominik HrebíkPavel Plevka
Mar 5, 2021·Journal of Virology·Liya MukhamedovaPavel Plevka

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Related Papers

Annual Review of Entomology
Bryony C Bonning, W Allen Miller
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme
Nobuhiko Nakashima
Proceedings of the National Academy of Sciences of the United States of America
Karel ŠkubníkPavel Plevka
© 2021 Meta ULC. All rights reserved