Virologic and immunologic outcomes after 24 weeks in HIV type 1-infected adolescents receiving highly active antiretroviral therapy

The Journal of Infectious Diseases
Patricia M FlynnPediatric AIDS Clinical Trial Group 381 Study Team

Abstract

Adolescents represent the fastest growing demographic group of new human immunodeficiency virus (HIV) infections in the United States. At present, there is little information available about their response to therapy. We studied 120 adolescents infected via high-risk behaviors who began receiving highly active antiretroviral therapy (HAART), to determine their virologic and immunologic response to therapy. Subjects were enrolled at 28 sites of the Pediatric Acquired Immunodeficiency Syndrome Clinical Trials Group. After 16-24 weeks of HAART, 59% of subjects had reproducible undetectable virus loads, according to repeat measurements (virologic success). As enumerated by flow-cytometric analysis, increases in levels of CD4 helper cells (both naive and memory) and decreases in levels of CD8 suppressor cells were observed. Partial restoration of some immunologic parameters for patients who did not achieve virologic success was also observed, but to a more limited extent than for adolescents with virologic success. Adherence to HAART was the only predictor of achieving undetectable virus loads. Adolescents have the capacity to improve their immunologic status with HAART. Lower than expected success in virologic control is related to...Continue Reading

Citations

Aug 19, 2005·Current Infectious Disease Reports·Marina Catallozzi, Donna C Futterman
Oct 27, 2007·AIDS Research and Human Retroviruses·Patricia M FlynnUNKNOWN PACTG 381 Study Team
Mar 21, 2006·AIDS Research and Human Retroviruses·Bret J RudyUNKNOWN Pediatric Aids Clinical Trials Group 381 Study Team
Jun 19, 2009·AIDS Research and Human Retroviruses·Bret J RudyUNKNOWN Adolescent Trials Network for HIV/AIDS Interventions
Oct 30, 2009·AIDS Patient Care and STDs·Caroline FosterUNKNOWN Collaborative HIV Paediatric Study (CHIPS)
Oct 30, 2009·AIDS Patient Care and STDs·Bret J RudyUNKNOWN Adolescent Trials Network for HIV/AIDS Interventions
Jan 30, 2013·Journal of Pediatric Psychology·Sylvie Naar-KingUNKNOWN Adolescent Medicine Network for HIV/AIDS Interventions
Aug 6, 2010·Journal of Tropical Pediatrics·Maria Leticia Santos CruzUNKNOWN NISDI Pediatric Study Group 2010
May 9, 2008·Clinical Obstetrics and Gynecology·Lisa M Henry-Reid, Jaime Martinez
Jun 4, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Allison L AgwuUNKNOWN HIV Research Network
Dec 21, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Edva NoelSerena P Koenig
Aug 1, 2007·Antimicrobial Agents and Chemotherapy·Patricia M FlynnUNKNOWN PACTG P1012 Team
Jan 26, 2011·Pediatrics·Elizabeth Peacock-VilladaGrace C John-Stewart
Jan 15, 2009·Bulletin of the World Health Organization·Macarthur CharlesDaniel W Fitzgerald
Mar 8, 2014·AIDS Patient Care and STDs·Brian C Zanoni, Kenneth H Mayer
Dec 2, 2015·Journal of the Pediatric Infectious Diseases Society·Kelly A DoughertyVirginia A Stallings
Feb 9, 2013·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Babafemi TaiwoRonald J Bosch
Jun 2, 2010·Infection·C GiaquintoUNKNOWN Italian Paediatric HIV Infection Working Group
Apr 3, 2008·Expert Review of Anti-infective Therapy·Mehri S McKellarRobert Colebunders
Apr 25, 2012·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Allison L AgwuKelly A Gebo
Jul 16, 2011·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·C Valdivia VadellC Figueras Nadal
Oct 26, 2010·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Patricia A GarvieJ Christopher Young
Mar 21, 2007·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Chokechai RongkavilitPraphan Phanuphak
May 1, 2013·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Tamar C RenaudColin W Shepard
May 5, 2009·Journal of Multivariate Analysis·Hua Liang
Jul 30, 2016·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Gabriela RicciCarlos Brites
Jan 27, 2009·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Patricia A GarvieUNKNOWN Pediatric AIDS Clinical Trials Group 1036A Study Team
Mar 19, 2014·Journal of the International Association of Providers of AIDS Care·Amisha MalhotraAnna Petrova

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