PMID: 15220701Jun 29, 2004Paper

Virologic and immunologic response to highly active antiretroviral therapy in indigenous and nonindigenous HIV-1-infected patients in the Netherlands

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Jeannine F NellenJan M Prins

Abstract

To compare the results of antiretroviral treatment (highly active antiretroviral therapy [HAART]) in indigenous Dutch (ID) and nonindigenous HIV-1-infected patients in Amsterdam, the Netherlands. We focused on the largest groups of nonindigenous people visiting our outpatient clinic: patients from other industrialized countries (western), from Surinam/Netherlands Antilles (SNA), and from sub-Saharan Africa (SSA). Retrospective cohort analysis of 692 therapy-naive HIV-1-positive individuals who visited our outpatient clinic for the first time between July 1, 1996 and December 31, 2001. We compared the groups at the time of their first visit to our clinic; at the start of HAART; and according to the virological, immunologic, and clinical treatment response during the 96 weeks after the start of HAART. Of the patients starting antiretroviral therapy, 362 were ID, 84 were western, 72 were from SNA, and 110 were from SSA. SNA and SSA patients had a lower CD4 cell count at first visit (ID = 330 cells/mm(3), western = 330 cells/mm(3), SNA = 250 cells/mm(3), and SSA = 170 cells/mm(3); P = 0.0002). Treatment in SNA and SSA patients was also started at a lower CD4 cell count, but the plasma HIV-1 RNA level was comparable. After the start...Continue Reading

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Citations

Jun 28, 2008·AIDS Patient Care and STDs·Silvia CostarelliGiampiero Carosi
Nov 24, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Inma JarrinUNKNOWN CASCADE Collaboration in EuroCoord
Oct 7, 2009·International Journal of Epidemiology·Mojgan Hessamfar-BonarekUNKNOWN Mortalité 2000 & 2005 Study Groups
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Sep 23, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Cornelia StaehelinUNKNOWN Swiss HIV Cohort Study
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