PMID: 8970472Dec 15, 1996Paper

Virologic and serologic markers of rapid progression to AIDS after HIV-1 seroconversion

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association
H FarzadeganJ Margolick

Abstract

The association between early virologic and immunologic events after human immunodeficiency virus type 1 (HIV-1) infection and progression of HIV-1 infection to acquired immunodeficiency syndrome (AIDS) was studied among 59 homosexual men with documented time of seroconversion. Epidemiologic factors, such as number of lifetime sexual partners, history of sexually transmitted diseases, and other factors, also were studied. All 17 seroconverters in the cohort who developed AIDS within 3 years (rapid progressors = RPs) were compared with 42 men without AIDS for at least 6 years seroconversion (nonrapid progressors = non-RPs). Plasma levels of HIV-1 RNA, p24 antigen, antibodies to HIV-1 structural genes, beta-2 microglobulin, neopterin, and interferon-alpha were measured at four time points: (a) the last seronegative visit, (b) the first seropositive visit, (c) the visit closest to AIDS (or the corresponding visit for the non-RPs) and (d) 6 years after seroconversion (for non-RPs). Up to seroconversion, the RPs had a significantly higher number of lifetime sexual partners than non-RPs (503 versus 171, respectively). At the first seropositive visit, RPs had significantly higher concentrations of plasma HIV-1 RNA (p < 0.01) and preva...Continue Reading

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Citations

Mar 10, 2001·The New England Journal of Medicine·T R SterlingT C Quinn
Sep 6, 2002·The New England Journal of Medicine·Stephanie JostLuc Perrin
Dec 13, 2005·Sexual Health·Don E Smith, Derek J Chan
Nov 13, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Xiaojie HuangHao Wu
Sep 25, 2002·Clinics in Laboratory Medicine·Monique R FergusonWilliam A O'Brien
May 3, 2000·Medical Hypotheses·A Yabrov
Oct 31, 2017·The Journal of Clinical Investigation·Rebecca T VeenhuisAndrea L Cox
Sep 16, 1998·AIDS Research and Human Retroviruses·S J PopperP J Kanki
May 3, 2000·AIDS Research and Human Retroviruses·L A Obert, E A Hoover
Sep 11, 2004·Clinical and Diagnostic Laboratory Immunology·Sunwoong S ChoiRobert L Roberts
Aug 8, 2009·European Journal of Medical Research·C KoeglUNKNOWN Ac-DAG Study Group

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