Virologic failure among children taking lopinavir/ritonavir-containing first-line antiretroviral therapy in South Africa

The Pediatric Infectious Disease Journal
Tammy MeyersGert U van Zyl

Abstract

To report the outcomes, clinical management decisions and results of resistance testing among a group of children who developed virologic failure on first-line lopinavir/ritonavir (LPV/r)-based therapy from a large cohort of antiretroviral therapy-treated children in Soweto. Historical cohort study. Children with virologic failure were identified from a group of 1692 children <3 years who had initiated first-line LPV/r-containing therapy since 2000 up to the end November 2011. Genotyping was conducted in some children, and outcomes, management decisions and resistance results were described. A total of 152 children with virologic failure on first-line LPV/r-containing antiretroviral therapy were included. Resistance testing was performed in 75/152 (49%), and apart from a younger age (11.1 vs. 15.1 months, P = 0.04), the children with versus those without resistance testing were similar for baseline characteristics (weight, CD4, viral load and time to failure). Genotyping revealed that 8/75 (10.7%) had significant LPV/r-associated resistance mutations, including 2 with intermediate darunavir resistance. Among 63/75 (84%) children remaining on LPV/r-based therapy, 32/63 (51%) achieved virologic suppression, and 2 of these childre...Continue Reading

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Citations

Sep 1, 2015·Current Infectious Disease Reports·Olatunji AdetokunbohMojisola Oluwasanu
Mar 30, 2017·PloS One·Patricia Rojas SánchezUNKNOWN Madrid Cohort of HIV-1 Infected Children and Adolescents Integrated in the Paediatric Branch of the Spanish National AIDS Ne
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Mar 2, 2019·Current Infectious Disease Reports·J Nuttall, V Pillay
Aug 1, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Stephanie HackettElaine J Abrams

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