Virological and immunological correlates of mother-to-child transmission of cytomegalovirus in The Gambia.

The Journal of Infectious Diseases
Steve KayeArnaud Marchant

Abstract

Cytomegalovirus (CMV) is the most common congenital infection and can follow primary and recurrent maternal infection. We studied correlates of vertical transmission of CMV in The Gambia, where most children acquire CMV during the first year of life. A cohort of 281 mothers and infants was recruited at birth. Infants were prospectively followed up for CMV infection during the first year of life. Excretion of CMV and antiviral immune response were studied at birth in mothers of children infected in utero, early during infancy, or late during infancy or not infected at 1 year of age. Congenital infection was diagnosed in 3.9% of newborns, and 85% of children were infected by 1 year. Excretion of CMV in colostrum or in the genital tract was more common in mothers of congenitally (100%) or early infected children (48%) than in mothers of late-infected (20%) or uninfected children (27%). Higher rates of viral excretion were associated with significantly higher levels of serum anti-CMV immunoglobulin G and higher frequencies of CMV-specific CD4+ T cells. In the context of recurrent maternal infection, transmission of CMV in utero and during early postnatal life is associated with excretion of the virus in colostrum and the genital tr...Continue Reading

References

Aug 1, 1985·The Journal of Infectious Diseases·R F Pass
May 5, 1973·British Medical Journal·H Stern, S M Tucker
Jul 5, 1973·The New England Journal of Medicine·D W ReynoldsC A Alford
May 8, 1980·The New England Journal of Medicine·S StagnoC A Alford
Aug 10, 1999·The Pediatric Infectious Disease Journal·S A Plotkin
Feb 13, 2001·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·W PreiserH F Rabenau
May 3, 2001·The New England Journal of Medicine·S B BoppanaW J Britt
Jul 20, 2001·Journal of Virology·C Söderberg-NauclérJ A Nelson
Apr 3, 2002·Nature Medicine·Victor AppaySarah L Rowland-Jones
Sep 28, 2002·The Journal of Infectious Diseases·Per Ljungman
Feb 25, 2003·JAMA : the Journal of the American Medical Association·Karen B FowlerRobert F Pass
Jun 3, 2004·Human Immunology·Tiziana LazzarottoMaria Paola Landini
Apr 9, 2005·Trends in Microbiology·Lenore PereiraTakako Tabata
Jan 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Douglas D TaylorCicek Gercel-Taylor
Mar 7, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lucia Mincheva-NilssonVladimir Baranov
Jun 9, 2006·The Journal of General Virology·John Sinclair, Patrick Sissons
Jul 18, 2006·Trends in Immunology·Ian L SargentChristopher W G Redman

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Citations

Dec 15, 2010·The Pediatric Infectious Disease Journal·Marco ZampoliHeather J Zar
Jul 21, 2009·AIDS·Jennifer A SlykerSarah L Rowland-Jones
Feb 18, 2016·Journal of Tropical Pediatrics·Rosauro VaroRalf Weigel
Jun 5, 2012·Diagnostic Microbiology and Infectious Disease·Michael FormanRavit Arav-Boger
Nov 26, 2015·The Journal of Infectious Diseases·Sascha R EllingtonAthena P Kourtis
Mar 26, 2009·Journal of Medical Virology·Matthew BatesUrsula A Gompels
Jun 16, 2011·Reviews in Medical Virology·Michael J CannonD Scott Schmid
Sep 22, 2012·Journal of Medical Virology·Raymond P StoweJames S Goodwin
Jan 9, 2013·Journal of Medical Virology·Joppe NijmanMalgorzata A Verboon-Maciolek
Dec 12, 2013·Clinical and Experimental Immunology·L AfranS L Rowland-Jones
Oct 7, 2015·Virology Journal·Augustin Etile AnohBernhard Ehlers
Mar 12, 2011·Journal of Medical Microbiology·Ashley L SchoenfischMichael J Cannon
Apr 19, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Anna ManiaIwona Mozer-Lisewska
Jan 30, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ricardo V Narvaez-ArzateCarolina Villegas-Alvarez
Jun 4, 2013·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Nei-Yuan HsiaoDiana Hardie
Dec 30, 2014·Cellular & Molecular Immunology·A Louise McCormick, Edward S Mocarski
Nov 18, 2014·Frontiers in Immunology·Ariane HuygensArnaud Marchant
Jan 6, 2017·Viral Immunology·Augustin Etile AnohBernhard Ehlers
Mar 1, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nayara G BarbosaMarisa M Mussi-Pinhata
Mar 5, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Louis-Marie YindomSarah L Rowland-Jones
Jul 31, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·David J C MilesPaul Moss
Oct 4, 2014·Expert Review of Anti-infective Therapy·Julia GunkelJoppe Nijman
Aug 9, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Abhinav AjaykumarHélène C F Côté
Sep 15, 2018·The Pediatric Infectious Disease Journal·Kristina AdachiUNKNOWN MPH for the NICHD HPTN 040 Study Team
Oct 24, 2020·The Journal of Infectious Diseases·Rana MinabSoren Gantt

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