Virological pattern of hepatitis B infection in an HIV-positive man with fatal fulminant hepatitis B: a case report.

Journal of Medical Case Reports
S BagaglioG Morsica

Abstract

There seem to be no published data concerning the clinical impact of populations of hepatitis B virus (HBV) in the hepatic and extrahepatic compartments of HIV-infected people with severe acute hepatitis. A 26-year-old Caucasian man presenting to our hospital with clinical symptoms suggesting acute hepatitis was found to have an acute hepatitis B profile upon admission. He developed fatal fulminant hepatitis and was found to be heavily immunocompromised due to HIV-1 infection. He had a high plasma HBV and HIV load, and analysis of the partial pre-S1/pre-S2 domain showed the presence of mixed infection with D and F genotypes. Analysis of the point mutations within this region revealed the presence of HBV strains with amino acid substitutions at the immunodominant epitopes involved in B or T cell recognition. A homogeneous population of a pre-core mutant strain harbouring the A1896G and A1899G affecting HBeAg expression was invariably found in the liver tissue, plasma and peripheral blood mononuclear cells despite active HBeAg secretion; it was the dominant strain in the liver only, and was characterised by the presence of two point mutations in the direct repeat 1 domain involved in HBV replication activity. Taken together, thes...Continue Reading

References

Jul 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S YotsumotoS Mishiro
Aug 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W F CarmanH C Thomas
Jun 1, 1993·Journal of Virology·J R Pollack, D Ganem
Feb 28, 2007·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Frank TackeChristian Trautwein
Nov 1, 2008·International Journal of Medical Sciences·Andrea LisottiGiuseppe Mazzella

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Citations

Aug 20, 2015·Hepatitis Monthly·Thomas MinaMahmoud Reza Pourkarim
Jan 26, 2017·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Thomas MinaMahmoud Reza Pourkarim
Aug 23, 2018·World Journal of Gastroenterology : WJG·Chun-Chen WuMeng-Ji Lu
Aug 1, 2018·Frontiers in Immunology·Sheila F LumleyPhilippa C Matthews

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Methods Mentioned

BETA
density-gradient centrifugation
PCR

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