Virological properties and nucleotide sequences of Cas-E-type endogenous ecotropic murine leukemia viruses in South Asian wild mice, Mus musculus castaneus

Journal of Virology
H IkedaT Tomita

Abstract

Two types of endogenous ecotropic murine leukemia viruses (MuLVs), termed AKV- and Cas-E-type MuLVs, differ in nucleotide sequence and distribution in wild mouse subspecies. In contrast to AKV-type MuLV, Cas-E-type MuLV is not carried by common laboratory mice. Wild mice of Mus musculus (M. m.) castaneus carry multiple copies of Cas-E-type endogenous MuLV, including the Fv-4(r) gene that is a truncated form of integrated MuLV and functions as a host's resistance gene against ecotropic MuLV infection. Our genetic cross experiments showed that only the Fv-4(r) gene was associated with resistance to ecotropic F-MuLV infection. Because the spontaneous expression of infectious virus was not detected in M. m. castaneus, we generated mice that did not carry the Fv-4(r) gene but did carry a single or a few endogenous MuLV loci. In mice not carrying the Fv-4(r) gene, infectious MuLVs were isolated in association with three of six Cas-E-type endogenous MuLV loci. The isolated viruses showed a weak syncytium-forming activity for XC cells, an interfering property of ecotropic MuLV, and a slight antigenic variation. Two genomic DNAs containing endogenous Cas-E-type MuLV were cloned and partially sequenced. All of the Cas-E-type endogenous M...Continue Reading

References

Jul 1, 1976·Journal of Virology·S RasheedE Chan
Sep 1, 1976·Journal of the National Cancer Institute·M B GardnerR J Huebner
Apr 11, 1991·Nucleic Acids Research·S M PerrymanJ L Portis
Jul 1, 1987·Journal of Virology·R R O'NeillC A Kozak
Dec 1, 1970·Virology·W P RoweJ W Hartley
Sep 1, 1973·Transplantation·F Listing
Feb 19, 1971·Nature·R H BassinP J Fischinger
Oct 15, 1981·Nature·T M ShinnickJ G Sutcliffe
Mar 1, 1980·The Journal of Experimental Medicine·M W CloydW P Rowe
Jan 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·M B GardnerS J O'Brien
Sep 1, 1981·Journal of Virology·S K ChattopadhyayD R Lowy
Jan 1, 1983·Journal of Virology·W KochR Friedrich
May 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·A S Khan, M A Martin
Feb 1, 1984·Journal of Virology·W Herr
Jun 1, 1993·Journal of Virology·K D Gray, M J Roth
Jan 1, 1994·Advances in Cancer Research·M B Gardner
Jul 1, 1993·Journal of Virology·T I LimjocoJ Silver
Jun 17, 1998·Journal of Virology·B Weimin WuW F Anderson

❮ Previous
Next ❯

Citations

Dec 2, 2010·Retrovirology·Christine A Kozak
Nov 8, 2007·PloS One·Marius LötscherRolf M Zinkernagel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.