Virology, pathogenesis, diagnosis and in-line treatment of COVID-19

European Journal of Pharmacology
Pavan Kumar SamudralaAmit Alexander

Abstract

SARS-CoV-2, a newly emerged pathogen in December 2019, marked as one of the highly pathogenic Coronavirus, and altogether this is the third coronavirus attack that crossed the species barrier. As of 1st July 2020, it is spreading around 216 countries, areas or territories, and a total of 10,185,374 and 503,862 confirmed cases and death reports, respectively. The SARS-CoV-2 virus entered into the target cells by binding with the hACE2 receptors. Spike glycoprotein promotes the entry of the virus into host target cells. Literature reported a significant mutation in receptor binding sites and membrane proteins of the previous SARS-CoV to turned as SARS-CoV-2 virus, responsible for most dreadful pandemic COVID-19. These modifications may be the probable reason for the extreme transmission and pathogenicity of the virus. A hasty spread of COVID-19 throughout the world is highly threatening, but still, scientists do not have a proper therapeutic measure to fight with it. Scientists are endeavoring across the world to find effective therapy to combat COVID 19. Several drugs such as Remdesivir, Hydroxychloroquine, Chloroquine, Ribavirin, Ritonavir, Lopinavir, Favipiravir, Interferons, Bevacizumab, Azithromycin, etc. are currently under...Continue Reading

Citations

Aug 25, 2020·Journal of Medical Virology·Ji-Ming Chen
Nov 16, 2020·International Immunopharmacology·Arun KumarVishal Aggarwal
Feb 16, 2021·Frontiers in Physiology·Miquéias Lopes-PachecoPatricia Rieken Macedo Rocco
Nov 18, 2020·Respiratory Medicine·Mukta AgrawalAmit Alexander
Jun 29, 2021·Journal of Clinical Laboratory Analysis·Girish Chandra DashDebdutta Bhattacharya
Aug 5, 2021·Surgical Neurology International·Lucas Crociati MeguinsDionei Freitas de Morais
Jul 27, 2021·Saudi Journal of Biological Sciences·Ahmed ElshafeiMaher H Gomaa
Aug 7, 2021·Journal of Immunoassay & Immunochemistry·Madhulika PradhanNagendra Singh Chauhan

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