Virosomal influenza-vaccine induced immunity in HIV-infected individuals with high versus low CD4+ T-cell counts: clues towards a rational vaccination strategy

AIDS
Stefanie FritzChristoph Hess

Abstract

In a prospective influenza-vaccination trial we show that HIV-infected individuals with CD4 T-cell counts less than 350 microl were distinct from HIV-infected individuals with more than 350 CD4 T-cell counts/microl, and from HIV-negative individuals, in that an influenza-specific immunoglobulin M-response was absent and expansion of interferon-gamma-secreting CD4 T cells was impaired. By contrast, immunoglobulin G-responses were induced in all study groups. These data suggest that establishing broad influenza-specific (immunoglobulin G) B-cell memory prior to severe immunodeficiency is important.

References

Jan 1, 1990·International Immunology·P Vieira, K Rajewsky
Jan 1, 1993·Annual Review of Immunology·D C Parker
May 23, 1998·Annual Review of Immunology·I S Grewal, R A Flavell
Feb 11, 2004·The Journal of Experimental Medicine·Barbara J HebeisThomas H Winkler
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Apr 25, 2006·The Journal of Allergy and Clinical Immunology·Luigi D NotarangeloAnne Durandy
Mar 26, 2009·Nature Reviews. Immunology·Susan Moir, Anthony S Fauci

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Citations

Oct 28, 2010·Der Internist·B BaboueeM Battegay
Feb 19, 2015·Human Vaccines & Immunotherapeutics·Christoph T BergerChristoph Hess
Jun 22, 2019·The Journal of Experimental Medicine·Thomas LiechtiAlexandra Trkola
Jun 19, 2018·The Journal of Clinical Investigation·Eirini MoysiSavita Pahwa
Nov 5, 2020·The EMBO Journal·Sheetal KawOliver T Fackler

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