Virtual and real bench testing of a new percutaneous valve device: a case study.

EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
Giovanni BiglinoSilvia Schievano

Abstract

To validate patient-specific computational testing of a second-generation device for percutaneous pulmonary valve implantation (PPVI), against realistic in vitro data. Tests were initially carried out in a simple loading mode, performing a compliance test on a rapid prototyped cylinder. This model was reproduced computationally and validated against the experimental data. A second-generation PPVI stent-graft, with no valve mounted, was then deployed in a simplified cylindrical geometry, measuring its displacement when subjected to a pressure pulse. Experimental and computational measurements were in good agreement. Finally, having selected a patient regarded as unsuitable for first-generation PPVI, but potentially suitable for a second-generation device, the stent-graft was studied in the rapidly prototyped patient-specific right ventricular outflow tract (RVOT). Stent positioning and radial displacements with pulsatile flow were observed in a mock circuit using fluoroscopy imaging. Stent deformation and anchoring were measured both in vitro and computationally. Both tests indicated that the stent was well anchored in the RVOT, especially in the distal position, and its central region was rounded, ensuring, were a valve present...Continue Reading

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Citations

Jul 24, 2012·Annals of Biomedical Engineering·Claudio CapelliSilvia Schievano
Jan 18, 2013·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Giovanni BiglinoSilvia Schievano
Jul 25, 2013·Current Cardiology Reports·Michael A Quail, Andrew M Taylor
May 16, 2014·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Qi-Ling CaoZiyad M Hijazi
Apr 14, 2016·Biomedical Engineering Online·Benedetta BiffiGiovanni Biglino
Jun 20, 2015·Cardiology in the Young·Worakan PromphanThanarat Layangool
Nov 28, 2012·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Giovanni BiglinoUNKNOWN MOCHA Collaborative Group
Oct 17, 2013·Circulation. Cardiovascular Interventions·Doff B McElhinneySilvia Schievano
Aug 8, 2019·World Journal of Hepatology·Peter BangeasGeorgios Tsoulfas

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