Virtual angiography for visualization and validation of computational models of aneurysm hemodynamics

IEEE Transactions on Medical Imaging
Matthew D FordDavid A Steinman

Abstract

It has recently become possible to simulate aneurysmal blood flow dynamics in a patient-specific manner via the coupling of three-dimensional (3-D) X-ray angiography and cmputational fluid dynamics (CFD). Before such image-based CFD models can be used in a predictive capacity, however, it must be shown that they indeed reproduce the in vivo hemodynamic environment. Motivated by the fact that there are currently no techniques for adequately measuring complex blood velocity fields in vivo, in this paper we describe how cine X-ray angiograms may be simulated for the purpose of indirectly validating patient-sperific CFD models. Mimicking the radiological procedure, a virtual angiogram is constructed by first simulating the time-varying injection of contrast agent into a precomputed, patient-specific CFD model. A time-series of images is then constructed by simulating the attenuation of X-rays through the computed 3-D contrast-agent flow dynamics. Virtual angiographic images and residence time maps, here derived from an image-based CFD model of a giant aneurysm, are shown to be in excellent agreement wiith the corresponding clinical images and residence time maps, but only when the interaction between the quasisteady contrast agent ...Continue Reading

References

Apr 4, 2001·Annals of Biomedical Engineering·M R Kaazempur-Mofrad, C R Ethier
Jan 5, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·David A SteinmanJ David Spence
Jan 17, 2002·Journal of Neurosurgery·H Richard WinnG Britz
Jun 21, 2002·Neurological Research·Baruch B Lieber, Matthew J Gounis
Jul 17, 2004·Journal of Neurosurgery·Tor IngebrigtsenHenrik Schirmer
Apr 13, 2005·IEEE Transactions on Medical Imaging·Juan R CebralAlejandro Frangi
Apr 13, 2005·IEEE Transactions on Medical Imaging·Juan R Cebral, Rainald Löhner
Jun 24, 2005·Physics in Medicine and Biology·Zhijie WangHui Meng

Citations

Oct 22, 2011·Annals of Biomedical Engineering·Amirhossein ArzaniShawn C Shadden
Jun 5, 2013·Journal of Computational Physics·Leopold GrinbergGeorge Em Karniadakis
May 19, 2010·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Maria-Cruz Villa-UriolAlejandro Frangi
Apr 17, 2008·Journal of Biomechanical Engineering·Matthew D FordDavid A Steinman
Sep 29, 2009·Annual Review of Fluid Mechanics·Daniel M SforzaJuan R Cebral
Dec 10, 2009·Medical Physics·Baruch B LieberLiliana Cesar
Feb 26, 2008·Medical Physics·Stephen RudinKenneth R Hoffmann
Apr 26, 2014·AJNR. American Journal of Neuroradiology·C Karmonik
May 31, 2011·AJNR. American Journal of Neuroradiology·David A Steinman
Oct 3, 2014·Minimally Invasive Therapy & Allied Technologies : MITAT : Official Journal of the Society for Minimally Invasive Therapy·Takuro IshiiTatsuo Igarashi
Jul 4, 2012·Computer Methods and Programs in Biomedicine·Ignacio LarrabideAlejandro Frangi
Oct 29, 2010·Medical Engineering & Physics·G MulderF N van de Vosse
Jun 16, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·C KarmonikAlan B Lumsden
Jun 24, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jörg BrednoMax Wintermark
Nov 30, 2012·IEEE Transactions on Bio-medical Engineering·M Haithem BabikerDavid H Frakes
Jun 14, 2006·IEEE Transactions on Medical Imaging·Wilbur C K Wong, Albert C S Chung
Mar 28, 2016·International Journal of Computer Assisted Radiology and Surgery·Marco BoegelMarkus Kowarschik
Nov 30, 2012·Computational and Mathematical Methods in Medicine·Jürgen EndresArnd Dörfler
Aug 22, 2009·Computational Intelligence and Neuroscience·Pankaj K SinghD Rodney Hose
Nov 3, 2016·Computer Methods in Biomechanics and Biomedical Engineering·Olivia MiraucourtMarc Thiriet
Sep 5, 2014·Annals of Biomedical Engineering·Bong Jae Chung, Juan R Cebral
Mar 3, 2018·Cardiovascular Engineering and Technology·Brandon KovarovicChander Sadasivan
Jan 22, 2014·Circulation·Alexis S TurjmanElazer R Edelman
Jan 22, 2008·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Leonid GoubergritsHans-Christian Hege
Apr 20, 2014·The International Journal of Artificial Organs·Simon J SonntagUlrich Steinseifer
Jun 25, 2019·Journal of Biomechanical Engineering·Sergiy ZhukStephen Moore
Jun 29, 2016·Annals of Biomedical Engineering·Juan R CebralAnne M Robertson
Apr 30, 2020·Artificial Organs·Giulia LuraghiFrancesco Migliavacca
Jun 24, 2020·International Journal for Numerical Methods in Biomedical Engineering·Sabrina R LynchC Alberto Figueroa

Related Concepts

Blood Flow Velocity
Diastolic Blood Pressure
Mycotic Aneurysm, Intracranial
Cerebral Angiography
Computer Graphics
In Silico
Digital Radiography
Radiographic Image Interpretation, Computer-Assisted
Virtual Systems

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