Aug 13, 2017

Virtual cardiac monolayers for electrical wave propagation

Scientific Reports
Nina KudryashovaAlexander V Panfilov

Abstract

The complex structure of cardiac tissue is considered to be one of the main determinants of an arrhythmogenic substrate. This study is aimed at developing the first mathematical model to describe the formation of cardiac tissue, using a joint in silico-in vitro approach. First, we performed experiments under various conditions to carefully characterise the morphology of cardiac tissue in a culture of neonatal rat ventricular cells. We considered two cell types, namely, cardiomyocytes and fibroblasts. Next, we proposed a mathematical model, based on the Glazier-Graner-Hogeweg model, which is widely used in tissue growth studies. The resultant tissue morphology was coupled to the detailed electrophysiological Korhonen-Majumder model for neonatal rat ventricular cardiomyocytes, in order to study wave propagation. The simulated waves had the same anisotropy ratio and wavefront complexity as those in the experiment. Thus, we conclude that our approach allows us to reproduce the morphological and physiological properties of cardiac tissue.

  • References61
  • Citations6

References

Mentioned in this Paper

Study
Specimen Type - Fibroblasts
Science of Morphology
Immunofluorescence Microscopy
Immunocytochemistry
Theoretical Study
Joints
Heart Tissue
Tissue Growth
Structure

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