Abstract
To assess the accuracy of liver iron content (LIC) quantification and grading ability associated with clinical LIC stratification using virtual iron concentration (VIC) imaging on dual-energy CT (DECT) in an iron overload rabbit model. Fifty-one rabbits were prepared as iron-loaded models by intravenous injection of iron dextran. DECT was performed at 80 and 140 kVp. VIC images were derived from an iron-specific algorithm. Postmortem LIC assessments were conducted on an inductively coupled plasma (ICP) spectrometer. Correlation between VIC and LIC was analyzed. VIC were stratified according to the corresponding clinical LIC thresholds of 1.8, 3.2, 7.0, and 15.0 mg Fe/g. Diagnostic performance of stratification was evaluated by receiver operating characteristic analysis. VIC linearly correlated with LIC (r = 0.977, P < 0.01). No significant difference was observed between VIC-derived LICs and ICP (P > 0.05). For the four clinical LIC thresholds, the corresponding cutoff values of VIC were 19.6, 25.3, 36.9, and 61.5 HU, respectively. The highest sensitivity (100%) and specificity (100 %) were achieved at the threshold of 15.0 mg Fe/g. Virtual iron concentration imaging on DECT showed potential ability to accurately quantify and s...Continue Reading
References
Jul 1, 1982·Investigative Radiology·H I GoldbergM Federle
Dec 30, 1982·The New England Journal of Medicine·G M BrittenhamE M Bellon
Feb 16, 1980·British Medical Journal·R W ChapmanL Kreel
Apr 1, 1995·British Journal of Haematology·E AngelucciM Ripalti
Aug 3, 2000·The New England Journal of Medicine·E AngelucciG Lucarelli
Dec 2, 2000·Transfusion Science·P NielsenR Fischer
Jun 6, 2003·British Journal of Haematology·Roland FischerAntonio Piga
Apr 9, 2004·Lancet·Y GandonY Deugnier
Jul 17, 2004·Blood·Timothy G St PierreRobert Lindeman
Dec 23, 2004·Epidemiology·Enrique F SchistermanHoward Bondell
Jan 5, 2005·Journal of Hepatology·Antonello Pietrangelo
Apr 30, 2005·Blood·John C WoodThomas D Coates
Dec 8, 2006·European Radiology·Thorsten R C JohnsonChristoph R Becker
Jun 21, 2008·Radiology·Fred A MettlerMahadevappa Mahesh
Mar 7, 2009·Blood·Jane S HankinsClaudia M Hillenbrand
Dec 10, 2009·Investigative Radiology·Paul StolzmannHatem Alkadhi
Aug 10, 2010·European Radiology·Agustin CastiellaMaria I Díez
Jan 14, 2011·The New England Journal of Medicine·Gary M Brittenham
Jan 26, 2011·Investigative Radiology·Michael A FischerRobert Goetti
Apr 8, 2011·European Radiology·Michael A FischerHatem Alkadhi
Nov 23, 2011·Radiology·Eugene JoeByung Ihn Choi
Dec 6, 2011·European Radiology·Perry J PickhardtEun Sil Yu
Mar 13, 2012·Transfusion·Juliano Lara Fernandes
Aug 25, 2012·Blood·A Victor HoffbrandMaria Domenica Cappellini
Nov 1, 2012·AJR. American Journal of Roentgenology·Thorsten R C Johnson
Jun 28, 2013·World Journal of Hepatology·Manal A Hamed, Sanaa A Ali
Citations
Oct 17, 2016·Seminars in Roentgenology·Sooah Kim, William P Shuman
Feb 15, 2018·Nanomaterials·Murali K MattaRodney Rouse
Dec 5, 2017·Abdominal Radiology·Ruo-Kun LiWei-Bo Chen
Jun 1, 2017·Investigative Radiology·Andres F AbadiaRichard L Morin
Jan 29, 2020·Japanese Journal of Radiology·Quanmei MaYang Hou
Aug 11, 2020·Abdominal Radiology·Khaled Y ElbannaLuís S Guimarães
Apr 9, 2021·Frontiers in Oncology·Yao ZhangChun-Kang Chang
Jun 15, 2021·Dose-response : a Publication of International Hormesis Society·Luca BassoValentina Brancato
Nov 17, 2021·Journal of Applied Clinical Medical Physics·Jessica MillerMichael Lawless