Virtual localization of the seizure onset zone: Using non-invasive MEG virtual electrodes at stereo-EEG electrode locations in refractory epilepsy patients

NeuroImage. Clinical
Erika L Juárez-MartinezElisabeth C W van Straaten

Abstract

In some patients with medically refractory epilepsy, EEG with intracerebrally placed electrodes (stereo-electroencephalography, SEEG) is needed to locate the seizure onset zone (SOZ) for successful epilepsy surgery. SEEG has limitations and entails risk of complications because of its invasive character. Non-invasive magnetoencephalography virtual electrodes (MEG-VEs) may overcome SEEG limitations and optimize electrode placement making SOZ localization safer. Our purpose was to assess whether interictal activity measured by MEG-VEs and SEEG at identical anatomical locations were comparable, and whether MEG-VEs activity properties could determine the location of a later resected brain area (RA) as an approximation of the SOZ. We analyzed data from nine patients who underwent MEG and SEEG evaluation, and surgery for medically refractory epilepsy. MEG activity was retrospectively reconstructed using beamforming to obtain VEs at the anatomical locations corresponding to those of SEEG electrodes. Spectral, functional connectivity and functional network properties were obtained for both, MEG-VEs and SEEG time series, and their correlation and reliability were established. Based on these properties, the approximation of the SOZ was c...Continue Reading

Citations

May 14, 2020·Human Brain Mapping·Haatef PourmotabbedAbbas Babajani-Feremi
Feb 1, 2019·BMC Medical Informatics and Decision Making·Tian MeiYi Zhou
Nov 9, 2019·F1000Research·Christoph BaumgartnerSusanne Pirker
Aug 1, 2021·BMC Medical Informatics and Decision Making·Mengnan MaYi Zhou

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Software Mentioned

MaxFilter
Elekta Neuromag Oy
VE
MEG
BrainWave
SPSS
SEEG

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