Virtual screening of plant compounds and nonsteroidal anti-inflammatory drugs for inhibition of quorum sensing and biofilm formation in Salmonella

Microbial Pathogenesis
Felipe Alves de AlmeidaMaria Cristina Dantas Vanetti

Abstract

Salmonella belongs to the Enterobacteriaceae family which is widely distributed in the environment due to its adaptive capacity to stress conditions. In addition, Salmonella is able to perform a type of cell-to-cell communication called quorum sensing, which leads to differential gene expression. The quorum sensing system mediated by AI-1, acyl homoserine lactones (AHLs), is incomplete in Salmonella because the luxI homolog gene, which encodes for AI-1 synthase, is missing in the genome. However, a homologue of LuxR, known as SdiA, is present and allows the detection of signaling molecules produced by other species of bacteria, leading to regulation of gene expression, mainly related to virulence and biofilm formation. Thus, in view of the importance of quorum sensing on the physiology regulation of microorganisms, the aim of the present study was to perform a virtual screening of plant compounds and nonsteroidal anti-inflammatory drugs (NASIDs) for inhibition of quorum sensing by molecular docking and biofilm formation in Salmonella. In general, most plant compounds and all NSAIDs bound in, at least, one of the three modeled structures of SdiA proteins of Salmonella Enteritidis PT4 578. In addition, many tested compounds had h...Continue Reading

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Citations

Jan 18, 2019·Revista Da Sociedade Brasileira De Medicina Tropical·Andria Lopes CruzMaxwel Adriano Abegg
May 28, 2019·Journal of Food Science·Milagros Liseth Castillo RiveraUelinton Manoel Pinto
Jun 13, 2020·Frontiers in Microbiology·Catarina A SantosUelinton M Pinto
Sep 15, 2020·Infection and Drug Resistance·Fatemeh HemmatiMohammad Ahangarzadeh Rezaee
May 21, 2019·Frontiers in Microbiology·B X V QuecanU M Pinto
Jan 21, 2020·Food Research International·Christina SakarikouEfstathios Giaouris
Jan 30, 2021·Biofouling·Fábio G MartinsSérgio F Sousa
Apr 30, 2021·Molecular Biotechnology·Fatemeh HemmatiPourya Gholizadeh
Aug 22, 2021·Archives of Microbiology·Erika Lorena Giraldo VargasMaria Cristina Dantas Vanetti
Oct 2, 2021·Frontiers in Microbiology·Catarina Angeli SantosUelinton Manoel Pinto

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