Virtualization of open-source secure web services to support data exchange in a pediatric critical care research network

Journal of the American Medical Informatics Association : JAMIA
Lewis J FreyJ Michael Dean

Abstract

To examine the feasibility of deploying a virtual web service for sharing data within a research network, and to evaluate the impact on data consistency and quality. Virtual machines (VMs) encapsulated an open-source, semantically and syntactically interoperable secure web service infrastructure along with a shadow database. The VMs were deployed to 8 Collaborative Pediatric Critical Care Research Network Clinical Centers. Virtual web services could be deployed in hours. The interoperability of the web services reduced format misalignment from 56% to 1% and demonstrated that 99% of the data consistently transferred using the data dictionary and 1% needed human curation. Use of virtualized open-source secure web service technology could enable direct electronic abstraction of data from hospital databases for research purposes.

References

Jun 2, 2006·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Douglas F WillsonCarol Nicholson
May 12, 2007·Methods of Information in Medicine·Sebastian GardeSam Heard
Jul 2, 2008·Journal of Biomedical Informatics·Catalina Martínez-CostaJosé Alberto Maldonado
May 6, 2009·Health Affairs·Kenneth H Buetow, John Niederhuber
May 6, 2009·Health Affairs·Randall Walker
Jul 2, 2009·Journal of the American Medical Informatics Association : JAMIA·Griffin M WeberIsaac S Kohane
Mar 2, 2010·Journal of the American Medical Informatics Association : JAMIA·Shawn N MurphyIsaac Kohane
Nov 12, 2010·Science Translational Medicine·Charles P FriedmanDavid Blumenthal
Oct 28, 2011·Clinical Pharmacology and Therapeutics·S TohJ S Brown
Jan 25, 2012·Pharmacoepidemiology and Drug Safety·Richard PlattMark G Weiner
Jan 1, 2011·Applied Clinical Informatics·P PayneA Lai
May 14, 2014·Journal of the American Medical Informatics Association : JAMIA·Kenneth D MandlShawn N Murphy
May 14, 2014·Journal of the American Medical Informatics Association : JAMIA·Abel N KhoUNKNOWN CAPriCORN Team
May 14, 2014·Journal of the American Medical Informatics Association : JAMIA·Elizabeth A McGlynnMichael G Kahn
May 14, 2014·Journal of the American Medical Informatics Association : JAMIA·Rachael L FleurenceJeffrey S Brown
May 14, 2014·Journal of the American Medical Informatics Association : JAMIA·Francis S CollinsMichael S Lauer
Jun 5, 2014·The New England Journal of Medicine·Bruce M Psaty, Alasdair M Breckenridge

❮ Previous
Next ❯

Citations

Jun 9, 2016·Journal of the American Medical Informatics Association : JAMIA·Lewis J FreyJoshua C Denny
Mar 2, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Allan DoctorKatri Typpo
Feb 6, 2017·Journal of Biomedical Semantics·Yasar KhanRatnesh Sahay
Jul 2, 2017·International Journal of Health Geographics·Jan van de KassteeleCarolien van den Brink

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of AHIMA
K A Frawley, K S Durham
Science Translational Medicine
Jessica J Nadler, Gregory J Downing
Scientific American
Julian Dibbell
Database : the Journal of Biological Databases and Curation
David LandsmanB F Francis Ouellette
© 2021 Meta ULC. All rights reserved