Sep 13, 2005

Virtues and pitfalls of EAE for the development of therapies for multiple sclerosis

Trends in Immunology
Lawrence Steinman, Scott S Zamvil

Abstract

Experimental autoimmune encephalomyelitis (EAE) is a useful model for aiding the development of new treatments for MS. All therapies approved for MS ameliorate EAE. Two approved medications, glatiramer acetate and Natalizumab, were developed directly from studies in EAE. Several trials are ongoing in MS after success in EAE, including altered peptide ligands of myelin, DNA vaccines and statins. However, EAE has failed to predict the outcome of certain approaches. The reasons underlying such failures are discussed here.

  • References64
  • Citations108

Citations

Mentioned in this Paper

Laquinimod
Monoclonal Antibodies
Monoclonal antibodies, antineoplastic
PPARA wt Allele
T-Lymphocyte
Glatiramer acetate
Neurologic Manifestations
Anaphylaxis (Non Medication)
Leukoencephalopathy, Progressive Multifocal
Janiceps

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