Virulence and antimicrobial resistance in clinical Enterococcus faecium

International Journal of Antimicrobial Agents
H BillströmCarl Erik Nord

Abstract

The aim of the present study was to determine the occurrence of seven virulence determinants in Enterococcus faecium clinical blood culture isolates over a 6-year period and to investigate possible correlations between virulence and antibiotic resistance. Two hundred and sixty-three isolates were screened for the presence of genes coding for aggregation substance (asa1), cytolysin (cylA), collagen-binding protein (ace), Enterococcusfaecalis endocarditis antigen (efaA(fs)), enterococcal surface protein (esp(fm)), gelatinase (gelE) and hyaluronidase (hyl(fm)) by polymerase chain reaction. The minimum inhibitory concentrations (MICs) of ampicillin, ciprofloxacin, gentamicin, imipenem, linezolid and vancomycin were determined by the agar dilution method and the MIC of daptomycin was determined by Etest. The esp(fm) gene was found in 56% of the isolates, hyl(fm) in 4%, whilst the other virulence genes were detected only sporadically (< or = 1%). The level of antibiotic resistance was 77% to ampicillin, 90% to ciprofloxacin and 83% to imipenem; 5% of the isolates were resistant to vancomycin and 2% were resistant to gentamicin (high-level resistance, MIC > or = 500 mg/L). A significant correlation was found between the presence of es...Continue Reading

References

Mar 20, 2002·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·N El AminB Wretlind
Oct 18, 2002·Antimicrobial Agents and Chemotherapy·David R MurdochL Barth Reller
Dec 10, 2003·Journal of Medical Microbiology·Roberta CretiLucilla Baldassarri
Jan 7, 2005·Journal of Clinical Microbiology·Adam N TreitmanGary A Noskin
Dec 24, 2005·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·I KlareW Witte
May 17, 2006·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·B LundC Edlund
Oct 19, 2006·International Journal of Food Microbiology·Maria de Fátima Silva LopesMaria Teresa Barreto Crespo
May 18, 2007·Brain and Cognition·Luis Augusto Teixeira, Maria Cândida Tocci Teixeira
Sep 11, 2007·Journal of Bacteriology·Esther HeikensRob J L Willems
Feb 19, 2008·FEMS Immunology and Medical Microbiology·Janetta TopMarc Bonten

❮ Previous
Next ❯

Citations

Jul 14, 2012·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M N Al-AhdalA A Al-Qahtani
Jun 12, 2013·Current Infectious Disease Reports·Katherine Reyes, Marcus Zervos
Jul 9, 2013·The Journal of Antimicrobial Chemotherapy·Irina StarikovaPål J Johnsen
Mar 1, 2012·Journal of Bacteriology·Margaret M C LamTimothy P Stinear
Oct 25, 2013·Indian Journal of Pathology & Microbiology·Hossein Samadi KafilMehdi Fourozandeh Moghadam
May 21, 2013·International Journal of Food Microbiology·Jong-Mi Choi, Gun-Jo Woo
Jan 15, 2014·Applied and Environmental Microbiology·Lauren M KopitMaria L Marco
May 15, 2013·Journal of Infection and Public Health·Narges DadfarmaHamideh Mahmoodzadeh Hosseini
Sep 24, 2011·Advances in Medical Sciences·B Kowalska-KrochmalG Gościniak
Jul 12, 2011·The Journal of Hospital Infection·I C V PalazzoA L da Costa Darini
Dec 17, 2009·International Journal of Antimicrobial Agents·Anna N BrilliantovaSergei V Sidorenko
Aug 8, 2015·Letters in Applied Microbiology·M EnayatiM Talebi
Aug 6, 2015·Journal of Medical Microbiology·Matthaios Papadimitriou-OlivgerisIris Spiliopoulou
Apr 23, 2009·Microbiology·Katie Fisher, Carol Phillips
Sep 11, 2012·Diagnostic Microbiology and Infectious Disease·Leila Priscilla Pinheiro da SilvaAna Lúcia da Costa Darini
Mar 15, 2015·International Journal of Environmental Research and Public Health·Wanxiang LiHuoyang Lv
May 20, 2017·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Ali JahansepasJalal Mardaneh
Aug 3, 2012·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Ka Hee KwonYong Ho Park
Apr 5, 2013·Clinical Microbiology Reviews·Alejandro BeceiroGermán Bou
Dec 1, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Michal DurackaEva Tvrda
Sep 11, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Chandrabhan RaoSeema Sood
Feb 12, 2017·Chonnam Medical Journal·Mohammad Reza ArabestaniSeyed Masoud Mousavi
Nov 20, 2019·Journal of Food Science and Technology·Liziane SchittlerWladimir Padilha da Silva
Apr 23, 2021·Porto Biomedical Journal·Oluwatosin Qawiyy OrababaOlusola Michael Solesi
Jul 3, 2021·Animals : an Open Access Journal From MDPI·Hyo Jung KangYoung Ju Lee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Carbapenems

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Carbapenems (ASM)

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.